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Details on Person COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex

Class:Id	Reaction:6799199
_displayName	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
_doRelease	TRUE
_timestamp	2024-05-16 14:50:40
authored	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
edited	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
input	[Complex:5689052] MCIA complex [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:60569] MT-ND6 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:59938] NDUFB6 [mitochondrial inner membrane] [Homo sapiens] [Complex:9708004] COA1:MT-ND2 [mitochondrial inner membrane] [Homo sapiens] [Complex:9708002] TMEM186:MT-ND3 [mitochondrial inner membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9908119] D'Eustachio, Peter, 2024-04-19 [InstanceEdit:9909139] D'Eustachio, Peter, 2024-04-29
isChimeric	FALSE
literatureReference	[LiteratureReference:5689024] Assembly factors for the membrane arm of human complex I [LiteratureReference:5689694] Assembly factors of human mitochondrial complex I and their defects in disease [LiteratureReference:9708008] Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I [LiteratureReference:9906637] FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy [LiteratureReference:9906635] Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I [LiteratureReference:9906974] Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module
modified	[InstanceEdit:6800865] Jassal, Bijay, 2015-09-30 [InstanceEdit:6801256] Jassal, Bijay, 2015-10-01 [InstanceEdit:9708005] Jassal, Bijay, 2020-11-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9906632] Stephan, Ralf, 2024-04-01 [InstanceEdit:9906971] Stephan, Ralf, 2024-04-04 [InstanceEdit:9908120] Stephan, Ralf, 2024-04-19 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 [InstanceEdit:9909138] Stephan, Ralf, 2024-04-29 [InstanceEdit:9910689] Stephan, Ralf, 2024-05-16
name	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
output	[Complex:6799190] 370 kDa subcomplex [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[Reaction:6799191] Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex [Homo sapiens] [Reaction:6799178] Intermediate 1 binds HP subcomplex to form Intermediate 2 [Homo sapiens] [Reaction:6799196] The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I [Homo sapiens] [Reaction:6799196] The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I [Homo sapiens] [Reaction:6799179] Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[Requirement:9906634] Requirement by 'FOXRED1 [mitochondrial inner membrane]' [Requirement:9906970] Requirement by 'SFXN4 [mitochondrial inner membrane]'
regulationReference	[RegulationReference:9906636] Requirement by 'FOXRED1 [mitochondrial inner membrane]' FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy [RegulationReference:9906973] Requirement by 'SFXN4 [mitochondrial inner membrane]' Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6801257] Meldal, Birgit, 2015-10-01 [InstanceEdit:9910688] Hill, David P, 2024-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812488] R-HSA-6799199.4
structureModified	[InstanceEdit:9906632] Stephan, Ralf, 2024-04-01 [InstanceEdit:9906971] Stephan, Ralf, 2024-04-04
summation	[Summation:6799180] Membrane arm subunits COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6 an...
(hasEvent)	[Pathway:6799198] Complex I biogenesis [Homo sapiens]
(precedingEvent)	[Reaction:6799202] The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776440] Update Tracker - [Reaction:6799199] COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex - v76:[addLiteratureReference, add_removeInput, modifyText] [_UpdateTracker:9911046] Update Tracker - [Reaction:6799199] COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex - v89:[addLiteratureReference, addRegulator, modifyText]
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No pathways have been reviewed or authored by COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (6799199)