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Details on Person Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex

Class:Id	Reaction:6799191
_displayName	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex
_doRelease	TRUE
_timestamp	2024-05-16 14:54:04
authored	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
edited	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
input	[Complex:6799181] Intermediate 2 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:60551] MT-ND1 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:5689127] NDUFAF5 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:5689130] NDUFAF6 [mitochondrial inner membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9908119] D'Eustachio, Peter, 2024-04-19 [InstanceEdit:9909139] D'Eustachio, Peter, 2024-04-29
isChimeric	FALSE
literatureReference	[LiteratureReference:5689024] Assembly factors for the membrane arm of human complex I [LiteratureReference:5689694] Assembly factors of human mitochondrial complex I and their defects in disease [LiteratureReference:9856314] Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function [LiteratureReference:9906772] A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis [LiteratureReference:9906775] Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I Deficiency [LiteratureReference:9906779] Defining mitochondrial protein functions through deep multiomic profiling
modified	[InstanceEdit:6801256] Jassal, Bijay, 2015-10-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9906777] Stephan, Ralf, 2024-04-02 [InstanceEdit:9906781] Stephan, Ralf, 2024-04-02 [InstanceEdit:9908120] Stephan, Ralf, 2024-04-19 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 [InstanceEdit:9909138] Stephan, Ralf, 2024-04-29 [InstanceEdit:9910689] Stephan, Ralf, 2024-05-16
name	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex
output	[Complex:6799189] 315kDa subcomplex [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[Reaction:6799178] Intermediate 1 binds HP subcomplex to form Intermediate 2 [Homo sapiens] [Reaction:6799203] IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 [Homo sapiens] [Reaction:6799196] The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I [Homo sapiens] [Reaction:6799179] Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[Requirement:9906766] Requirement by 'NDUFAF8 [mitochondrion]' [Requirement:9906783] Requirement by 'PYURF [mitochondrion]'
regulationReference	[RegulationReference:9906759] Requirement by 'NDUFAF8 [mitochondrion]' Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function [RegulationReference:9906794] Requirement by 'PYURF [mitochondrion]' Defining mitochondrial protein functions through deep multiomic profiling
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6801257] Meldal, Birgit, 2015-10-01 [InstanceEdit:9910688] Hill, David P, 2024-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812485] R-HSA-6799191.3
structureModified	[InstanceEdit:9906777] Stephan, Ralf, 2024-04-02 [InstanceEdit:9906781] Stephan, Ralf, 2024-04-02
summation	[Summation:6799201] A complex I intermediate of 315kDa (reestimated from the ori...
(hasEvent)	[Pathway:6799198] Complex I biogenesis [Homo sapiens]
(precedingEvent)	[Reaction:6799199] COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex [Homo sapiens] [Reaction:6799202] The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9910936] Update Tracker - [Reaction:6799191] Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex - v89:[addLiteratureReference, addRegulator, modifyText]
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