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Details on Person The hydrophobic protein fraction (HP) is assembled with NDUF...
| Class:Id | Summation:6799186 |
|---|---|
| _displayName | The hydrophobic protein fraction (HP) is assembled with NDUF... |
| _timestamp | 2024-04-19 07:21:50 |
| created | [InstanceEdit:6799182] Jassal, Bijay, 2015-09-22 |
| modified | [InstanceEdit:9906751] Stephan, Ralf, 2024-04-02 [InstanceEdit:9908118] Stephan, Ralf, 2024-04-19 |
| text | The hydrophobic protein fraction (HP) is assembled with NDUFA3, 8, 9 and 13 amongst many others and anchored to the inner mitochondrial membrane by Intermediate 1 assembly factors NDUFAF3 (C3orf60), NDUFAF4 (C6orf66) and TIMMDC1 (C3orf1) to form Intermediate 2 (Mckenzie & Ryan 2010, Andrews et al. 2013). LYR motif-containing protein 2 (LYRM2) interacts with Complex I pre-assembly complexes via the subunit NDUFAB1, subunit of HP, in a transient manner. LYRM2 knockout cell lines of HEK293T cells showed reduced levels of a subset of complex I subunits and assembly factors (Dibley et al., 2019). We chose to annotate it as a requirement for this reaction, but the exact mechanism of LYRM2 is still unclear. |
| (summation) | [Reaction:6799178] Intermediate 1 binds HP subcomplex to form Intermediate 2 [Homo sapiens] |
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No pathways have been reviewed or authored by The hydrophobic protein fraction (HP) is assembled with NDUF... (6799186)
