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Details on Person Intermediate 1 binds HP subcomplex to form Intermediate 2

Class:Id	Reaction:6799178
_displayName	Intermediate 1 binds HP subcomplex to form Intermediate 2
_doRelease	TRUE
_timestamp	2024-05-16 14:53:53
authored	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
edited	[InstanceEdit:6799182] Jassal, Bijay, 2015-09-22
input	[Complex:163929] HP subcomplex [mitochondrial inner membrane] [Homo sapiens] [Complex:6788529] Intermediate 1 [mitochondrial inner membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9908119] D'Eustachio, Peter, 2024-04-19 [InstanceEdit:9909139] D'Eustachio, Peter, 2024-04-29
isChimeric	FALSE
literatureReference	[LiteratureReference:5689024] Assembly factors for the membrane arm of human complex I [LiteratureReference:5689694] Assembly factors of human mitochondrial complex I and their defects in disease [LiteratureReference:9906757] The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly
modified	[InstanceEdit:6801256] Jassal, Bijay, 2015-10-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9906751] Stephan, Ralf, 2024-04-02 [InstanceEdit:9908120] Stephan, Ralf, 2024-04-19 [InstanceEdit:9909138] Stephan, Ralf, 2024-04-29 [InstanceEdit:9910689] Stephan, Ralf, 2024-05-16
name	Intermediate 1 binds HP subcomplex to form Intermediate 2
output	[Complex:6799181] Intermediate 2 [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[Reaction:6799203] IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 [Homo sapiens] [Reaction:6800868] NDUF subunits bind to form the IP subcomplex [Homo sapiens] [Reaction:6799196] The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[Requirement:9906753] Requirement by 'LYRM2 [mitochondrial matrix]'
regulationReference	[RegulationReference:9906755] Requirement by 'LYRM2 [mitochondrial matrix]' The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6801257] Meldal, Birgit, 2015-10-01 [InstanceEdit:9910688] Hill, David P, 2024-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812483] R-HSA-6799178.3
structureModified	[InstanceEdit:9906751] Stephan, Ralf, 2024-04-02
summation	[Summation:6799186] The hydrophobic protein fraction (HP) is assembled with NDUF...
(hasEvent)	[Pathway:6799198] Complex I biogenesis [Homo sapiens]
(precedingEvent)	[Reaction:6799191] Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9911101] Update Tracker - [Reaction:6799178] Intermediate 1 binds HP subcomplex to form Intermediate 2 - v89:[addLiteratureReference, addRegulator, modifyText]
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