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Details on Person E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter

Class:Id	Reaction:6798347
_displayName	E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter
_doRelease	TRUE
_timestamp	2017-01-27 15:29:26
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6798358] Orlic-Milacic, Marija, 2015-09-18
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:8953960] Orlic-Milacic, Marija, 2017-01-03 [InstanceEdit:8959606] Orlic-Milacic, Marija, 2017-01-27
input	[EntityWithAccessionedSequence:6798348] E2F1 gene [nucleoplasm] [Homo sapiens] [DefinedSet:8953034] E2F7,E2F8 dimers [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6798297] E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression [LiteratureReference:6798350] The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence [LiteratureReference:8953023] Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development [LiteratureReference:8953056] DNA-damage response control of E2F7 and E2F8 [LiteratureReference:8953005] E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes
modified	[InstanceEdit:6804132] Orlic-Milacic, Marija, 2015-10-08 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809236] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810438] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856095] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8953004] Orlic-Milacic, Marija, 2016-12-21 [InstanceEdit:8953041] Orlic-Milacic, Marija, 2016-12-21 [InstanceEdit:8953052] Orlic-Milacic, Marija, 2016-12-21 [InstanceEdit:8953058] Orlic-Milacic, Marija, 2016-12-21 [InstanceEdit:8953080] Orlic-Milacic, Marija, 2016-12-21 [InstanceEdit:8953963] Orlic-Milacic, Marija, 2017-01-03 [InstanceEdit:8953964] Orlic-Milacic, Marija, 2017-01-03 [InstanceEdit:8959607] Orlic-Milacic, Marija, 2017-01-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter
output	[Complex:6798354] E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8952996] E2F7 forms homodimers [Homo sapiens] [BlackBoxEvent:6798299] TP53 stimulates E2F7 expression [Homo sapiens] [Reaction:8953013] E2F7 binds E2F8 [Homo sapiens] [BlackBoxEvent:6798299] TP53 stimulates E2F7 expression [Homo sapiens] [Reaction:8953037] E2F8 forms homodimers [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8953962] Di Stefano, Luisa, 2017-01-03 [InstanceEdit:8959604] Westendorp, Bart, 2017-01-24 [InstanceEdit:8959602] de Bruin, Alain, 2017-01-24
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8953051] Orlic-Milacic, Marija, 2016-12-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860932] R-HSA-6798347.3
summation	[Summation:6798355] E2F7 binds to E2F sites in the promoter of the E2F1 gene to ...
(hasEvent)	[Pathway:6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:6798353] E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781977] Update Tracker - [Reaction:6798347] E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter - v60:[addLiteratureReference, add_removeInput, modifyText]
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