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Details on Person TP53 stimulates E2F7 expression

Class:Id	BlackBoxEvent:6798299
_displayName	TP53 stimulates E2F7 expression
_doRelease	TRUE
_timestamp	2016-02-19 18:22:29
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6798300] Orlic-Milacic, Marija, 2015-09-17
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:6798306] E2F7 Gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6798297] E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression [LiteratureReference:6798350] The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
modified	[InstanceEdit:6798360] Orlic-Milacic, Marija, 2015-09-18 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809236] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810438] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856095] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates E2F7 expression
output	[EntityWithAccessionedSequence:6798305] E2F7 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6798304] TP53 binds the E2F7 gene [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:6798310] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:E2F7 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641352] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:E2F7 Gene [nucleoplasm]' E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861381] R-HSA-6798299.4
summation	[Summation:6798308] Binding of TP53 (p53) to the p53 response element in the pro...
(hasEvent)	[Pathway:6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Homo sapiens]
(precedingEvent)	[Reaction:8952996] E2F7 forms homodimers [Homo sapiens] [Reaction:8953013] E2F7 binds E2F8 [Homo sapiens]
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No pathways have been reviewed or authored by TP53 stimulates E2F7 expression (6798299)