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Details on Person p-S15,S20-TP53 Tetramer:E2F4:(TFDP1,TFDP2):(RBL1,RBL2):CDC25C Gene [nucleoplasm]

Class:Id	Complex:6798290
_displayName	p-S15,S20-TP53 Tetramer:E2F4:(TFDP1,TFDP2):(RBL1,RBL2):CDC25C Gene [nucleoplasm]
_timestamp	2016-02-24 15:39:47
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6798277] Orlic-Milacic, Marija, 2015-09-17
hasComponent	[Complex:6798265] E2F4:(TFDP1,TFDP2):(RBL1,RBL2) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:68664] E2F4 [nucleoplasm] [Homo sapiens] [DefinedSet:1362227] TFDP1,TFDP2 [nucleoplasm] [Homo sapiens] [CandidateSet:6798269] RBL1,RBL2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6798280] CDC25C Gene [nucleoplasm] [Homo sapiens] [Complex:3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:69683] p-S15,S20-TP53 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:69683] p-S15,S20-TP53 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:69683] p-S15,S20-TP53 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:69683] p-S15,S20-TP53 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6798286] DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter [LiteratureReference:6798264] p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes
modified	[InstanceEdit:6799324] Orlic-Milacic, Marija, 2015-09-23 [InstanceEdit:8862039] Orlic-Milacic, Marija, 2016-02-24
name	p-S15,S20-TP53 Tetramer:E2F4:(TFDP1,TFDP2):(RBL1,RBL2):CDC25C Gene
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8858993] R-HSA-6798290.1
(output)	[Reaction:6798282] TP53 and E2F4 bind the CDC25C gene [Homo sapiens]
(regulator)	[NegativeGeneExpressionRegulation:6798285] Negative gene expression regulation by 'p-S15,S20-TP53 Tetramer:E2F4:(TFDP1,TFDP2):(RBL1,RBL2):CDC25C Gene [nucleoplasm]'
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No pathways have been reviewed or authored by p-S15,S20-TP53 Tetramer:E2F4:(TFDP1,TFDP2):(RBL1,RBL2):CDC25C Gene [nucleoplasm] (6798290)