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Details on Person TP53 and E2F4 bind the CDC25C gene

Class:IdReaction:6798282
_displayNameTP53 and E2F4 bind the CDC25C gene
_doReleaseTRUE
_timestamp2017-02-23 16:21:41
authored[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:6798277] Orlic-Milacic, Marija, 2015-09-17
edited[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input[Complex:6798265] E2F4:(TFDP1,TFDP2):(RBL1,RBL2) [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:6798280] CDC25C Gene [nucleoplasm] [Homo sapiens]
[Complex:3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:6798286] DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter
[LiteratureReference:6798264] p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes
modified[InstanceEdit:6798296] Orlic-Milacic, Marija, 2015-09-17
[InstanceEdit:6799324] Orlic-Milacic, Marija, 2015-09-23
[InstanceEdit:6804132] Orlic-Milacic, Marija, 2015-10-08
[InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09
[InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09
[InstanceEdit:6809236] Orlic-Milacic, Marija, 2015-11-09
[InstanceEdit:6810438] Orlic-Milacic, Marija, 2015-11-17
[InstanceEdit:8856096] Orlic-Milacic, Marija, 2016-02-08
[InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10
[InstanceEdit:8979254] Orlic-Milacic, Marija, 2017-02-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTP53 and E2F4 bind the CDC25C gene
output[Complex:6798290] p-S15,S20-TP53 Tetramer:E2F4:(TFDP1,TFDP2):(RBL1,RBL2):CDC25C Gene [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8860913] R-HSA-6798282.3
summation[Summation:6798295] The promoter of the CDC25C gene contains p53 response elemen...
(hasEvent)[Pathway:6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest [Homo sapiens]
(precedingEvent)[BlackBoxEvent:6798268] TP53 and E2F4 inhibit CDC25C expression [Homo sapiens]
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No pathways have been reviewed or authored by TP53 and E2F4 bind the CDC25C gene (6798282)
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