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Details on Person TP53 family members stimulate CASP1 expression

Class:Id	BlackBoxEvent:6798081
_displayName	TP53 family members stimulate CASP1 expression
_doRelease	TRUE
_timestamp	2016-02-19 18:22:29
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:6798087] Orlic-Milacic, Marija, 2015-09-16
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:6798089] CASP1 Gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6798097] Caspase-1 is a novel target of p63 in tumor suppression [LiteratureReference:6798096] Direct transcriptional activation of human caspase-1 by tumor suppressor p53 [LiteratureReference:6798080] Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin [LiteratureReference:6798118] Molecular cloning of the interleukin-1 beta converting enzyme [LiteratureReference:6798110] Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3 [LiteratureReference:451670] Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death
modified	[InstanceEdit:6798121] Orlic-Milacic, Marija, 2015-09-16 [InstanceEdit:6801416] Orlic-Milacic, Marija, 2015-10-01 [InstanceEdit:6803273] Orlic-Milacic, Marija, 2015-10-05 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809233] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810433] Orlic-Milacic, Marija, 2015-11-16 [InstanceEdit:6810437] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856081] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 family members stimulate CASP1 expression
output	[EntityWithAccessionedSequence:448692] CASP1(1-404) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:6798082] TP53 family members bind the CASP1 gene [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:6798105] Positive gene expression regulation by '(p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642587] Positive gene expression regulation by '(p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm]' Direct transcriptional activation of human caspase-1 by tumor suppressor p53
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861383] R-HSA-6798081.4
summation	[Summation:6798101] Upon binding to the p53 response element in the promoter of ...
(hasEvent)	[Pathway:6803207] TP53 Regulates Transcription of Caspase Activators and Caspases [Homo sapiens]
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No pathways have been reviewed or authored by TP53 family members stimulate CASP1 expression (6798081)