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Details on Person SLC22A4 transports BET from mitochondrial matrix to cytosol

Class:Id	Reaction:6797957
_displayName	SLC22A4 transports BET from mitochondrial matrix to cytosol
_doRelease	TRUE
_timestamp	2026-01-20 16:22:32
authored	[InstanceEdit:6797960] Jassal, Bijay, 2015-09-16
catalystActivity	[CatalystActivity:9979087] amino-acid betaine transmembrane transporter activity of SLC22A4 [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9979081] amino-acid betaine transmembrane transporter activity of SLC22A4 [mitochondrial outer membrane] Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2
compartment	[Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6797960] Jassal, Bijay, 2015-09-16
crossReference	[DatabaseIdentifier:9979057] RHEA:72115
edited	[InstanceEdit:6797960] Jassal, Bijay, 2015-09-16
input	[SimpleEntity:6798202] BET [mitochondrial matrix] [SimpleEntity:2889083] Na+ [mitochondrial matrix]
internalReviewed	[InstanceEdit:9979111] D'Eustachio, Peter, 2026-01-14
isChimeric	FALSE
literatureReference	[LiteratureReference:9979059] Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria [LiteratureReference:9979053] Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2 [LiteratureReference:9979064] Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies
modified	[InstanceEdit:6798167] Jassal, Bijay, 2015-09-17 [InstanceEdit:6798185] Jassal, Bijay, 2015-09-17 [InstanceEdit:6798189] Jassal, Bijay, 2015-09-17 [InstanceEdit:6798215] Jassal, Bijay, 2015-09-17 [InstanceEdit:8851786] Jassal, Bijay, 2016-01-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9979091] D'Eustachio, Peter, 2026-01-14 [InstanceEdit:9979110] D'Eustachio, Peter, 2026-01-14 [InstanceEdit:9979656] D'Eustachio, Peter, 2026-01-20
name	SLC22A4 transports BET from mitochondrial matrix to cytosol glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in) BET translocates from mitochondrial matrix to cytosol
output	[SimpleEntity:352015] BET [cytosol] [SimpleEntity:83910] Na+ [cytosol]
precedingEvent	[Reaction:6797955] ALDH7A1 oxidises BETALD to BET [Homo sapiens] [Reaction:6797961] CHDH oxidises Cho to BETALD [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11 [InstanceEdit:9979657] Hill, David P, 2026-01-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861379] R-HSA-6797957.3
structureModified	[InstanceEdit:9979091] D'Eustachio, Peter, 2026-01-14
summation	[Summation:6798218] SLC22A4 (Solute carrier family 22 member 4) associated with ...
(hasEvent)	[Pathway:6798163] Choline catabolism [Homo sapiens]
(precedingEvent)	[Reaction:1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984666] Update Tracker - [Reaction:6797957] SLC22A4 transports BET from mitochondrial matrix to cytosol - v96:[add_removeLiteratureReference, modifyText, removeCatalystActivity, removeInput, removeOutput]
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