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Details on Person ALDH7A1 oxidises BETALD to BET

Class:IdReaction:6797955
_displayNameALDH7A1 oxidises BETALD to BET
_doReleaseTRUE
_timestamp2026-01-20 16:22:27
authored[InstanceEdit:6797960] Jassal, Bijay, 2015-09-16
catalystActivity[CatalystActivity:6797959] betaine-aldehyde dehydrogenase (NAD+) activity of ALDH7A1 [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:6797960] Jassal, Bijay, 2015-09-16
crossReference[DatabaseIdentifier:9979067] RHEA:15306
edited[InstanceEdit:6797960] Jassal, Bijay, 2015-09-16
input[SimpleEntity:6798194] BETALD [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
internalReviewed[InstanceEdit:9979111] D'Eustachio, Peter, 2026-01-14
isChimericFALSE
literatureReference[LiteratureReference:6798203] Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress
modified[InstanceEdit:6798167] Jassal, Bijay, 2015-09-17
[InstanceEdit:6798185] Jassal, Bijay, 2015-09-17
[InstanceEdit:6798189] Jassal, Bijay, 2015-09-17
[InstanceEdit:6798212] Jassal, Bijay, 2015-09-17
[InstanceEdit:8851786] Jassal, Bijay, 2016-01-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9979091] D'Eustachio, Peter, 2026-01-14
[InstanceEdit:9979110] D'Eustachio, Peter, 2026-01-14
[InstanceEdit:9979656] D'Eustachio, Peter, 2026-01-20
nameALDH7A1 oxidises BETALD to BET
betaine aldehyde + NAD(+) + H2O => glycine betaine + NADH + 2 H(+)
output[SimpleEntity:6798202] BET [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
[InstanceEdit:9979657] Hill, David P, 2026-01-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8860909] R-HSA-6797955.3
structureModified[InstanceEdit:9979091] D'Eustachio, Peter, 2026-01-14
summation[Summation:6798208] Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) is a ...
(hasEvent)[Pathway:6798163] Choline catabolism [Homo sapiens]
(precedingEvent)[Reaction:6797957] SLC22A4 transports BET from mitochondrial matrix to cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984640] Update Tracker - [Reaction:6797955] ALDH7A1 oxidises BETALD to BET - v96:[removeOutput]
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