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Details on Person SARDH:FAD oxidatively demethylates SARC to Gly

Class:IdReaction:6797913
_displayNameSARDH:FAD oxidatively demethylates SARC to Gly
_doReleaseTRUE
_timestamp2026-01-20 16:22:31
authored[InstanceEdit:6797914] Jassal, Bijay, 2015-09-16
catalystActivity[CatalystActivity:6797935] sarcosine dehydrogenase activity of SARDH:FAD [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:6797914] Jassal, Bijay, 2015-09-16
crossReference[DatabaseIdentifier:9979095] RHEA:19794
edited[InstanceEdit:6797914] Jassal, Bijay, 2015-09-16
input[SimpleEntity:6797917] SARC [mitochondrial matrix]
[SimpleEntity:9979086] THFpolyGlu [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113596] FAD [mitochondrial matrix]
internalReviewed[InstanceEdit:9979111] D'Eustachio, Peter, 2026-01-14
isChimericFALSE
literatureReference[LiteratureReference:6797948] Mutations in the sarcosine dehydrogenase gene in patients with sarcosinemia
[LiteratureReference:6797947] Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia
[LiteratureReference:9979061] Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins
modified[InstanceEdit:6797928] Jassal, Bijay, 2015-09-16
[InstanceEdit:6797943] Jassal, Bijay, 2015-09-16
[InstanceEdit:6798167] Jassal, Bijay, 2015-09-17
[InstanceEdit:6798189] Jassal, Bijay, 2015-09-17
[InstanceEdit:8851786] Jassal, Bijay, 2016-01-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9979091] D'Eustachio, Peter, 2026-01-14
[InstanceEdit:9979110] D'Eustachio, Peter, 2026-01-14
[InstanceEdit:9979656] D'Eustachio, Peter, 2026-01-20
nameSARDH:FAD oxidatively demethylates SARC to Gly
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + oxidized (electron-transfer flavoprotein) + H(+) => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced (electron-transfer flavoprotein) + glycine
output[SimpleEntity:159549] Gly [mitochondrial matrix]
[SimpleEntity:31649] FADH2 [mitochondrial matrix]
[SimpleEntity:9979072] MeTHFpolyGlu [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
[InstanceEdit:9979657] Hill, David P, 2026-01-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8860912] R-HSA-6797913.3
structureModified[InstanceEdit:9979091] D'Eustachio, Peter, 2026-01-14
summation[Summation:6797944] Mitochondrial sarcosine dehydrogenase (SARDH) oxidatively de...
(hasEvent)[Pathway:6798163] Choline catabolism [Homo sapiens]
(precedingEvent)[Reaction:5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984611] Update Tracker - [Reaction:6797913] SARDH:FAD oxidatively demethylates SARC to Gly - v96:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
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