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Details on Person Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) b...

Class:IdSummation:6797886
_displayNameInterleukin-1 receptor accessory protein-like 1 (IL1RAPL1) b...
_timestamp2017-01-06 10:07:42
created[InstanceEdit:6797849] Garapati, Phani Vijay, 2015-09-16
literatureReference[LiteratureReference:6797772] A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation
[LiteratureReference:6797832] IL1RAPL1 associated with mental retardation and autism regulates the formation and stabilization of glutamatergic synapses of cortical neurons through RhoA signaling pathway
[LiteratureReference:6797817] The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPĪ“ and RhoGAP2
[LiteratureReference:6797787] Mutations in the calcium-related gene IL1RAPL1 are associated with autism
modified[InstanceEdit:8954236] Jupe, Steve, 2017-01-06
textInterleukin-1 receptor accessory protein-like 1 (IL1RAPL1) belongs to the interleukin-1/Toll receptor family. It has extracellular Ig-like domains and an intracellular Toll/IL1R (TIR) domain. It regulates synapse formation of cortical neurons. Trans-synaptic interaction between postsynaptic IL1RAPL1 and presynaptic Receptor-type tyrosine-protein phosphatase delta (PTPRD) bidirectionally regulates excitatory synapse development. IL1RAPL2 is related to IL1RAPL1 and may also function in excitatory synapse organization although with less potency than IL1RAPL1 (Yoshida et al. 2011, Valnegri et al. 2011). IL1RAPL1 is associated with cognitive diseases ranging from nonsyndromic X-linked mental retardation to autism (Hayashi et al. 2013, Piton et al. 2008, Carrie et al. 1999).
(summation)[Reaction:6797810] PTPRD binds IL1RAPL1 [Homo sapiens]
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