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Details on Person TP53 inhibits BIRC5 expression

Class:Id	BlackBoxEvent:6797763
_displayName	TP53 inhibits BIRC5 expression
_doRelease	TRUE
_timestamp	2017-02-23 15:44:14
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6797759] Orlic-Milacic, Marija, 2015-09-16
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:6797760] BIRC5 Gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6797755] Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
modified	[InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809233] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810429] Orlic-Milacic, Marija, 2015-11-16 [InstanceEdit:6810433] Orlic-Milacic, Marija, 2015-11-16 [InstanceEdit:6810437] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856083] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8979248] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 inhibits BIRC5 expression
output	[EntityWithAccessionedSequence:4655344] BIRC5 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6797766] TP53 binds the BIRC5 gene [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:6797757] Negative gene expression regulation by 'p-S15,S20-TP53 Tetramer:BIRC5 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642081] Negative gene expression regulation by 'p-S15,S20-TP53 Tetramer:BIRC5 Gene [nucleoplasm]' Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861386] R-HSA-6797763.5
summation	[Summation:6797764] Upon binding to the p53 response element in the promoter of ...
(hasEvent)	[Pathway:6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain [Homo sapiens]
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No pathways have been reviewed or authored by TP53 inhibits BIRC5 expression (6797763)