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Details on Person CDK12 stimulates expression of DNA repair genes

Class:Id	BlackBoxEvent:6797712
_displayName	CDK12 stimulates expression of DNA repair genes
_doRelease	TRUE
_timestamp	2019-03-21 00:15:28
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6797710] Orlic-Milacic, Marija, 2015-09-15
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[CandidateSet:6797615] DNA repair genes regulated by CDK12 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6797666] Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing [LiteratureReference:6797674] Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex [LiteratureReference:6797658] Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex [LiteratureReference:6797093] The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes [LiteratureReference:6797694] The structure and substrate specificity of human Cdk12/Cyclin K [LiteratureReference:6797716] Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors [LiteratureReference:6797685] Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II
modified	[InstanceEdit:6797722] Orlic-Milacic, Marija, 2015-09-15 [InstanceEdit:6797723] Orlic-Milacic, Marija, 2015-09-15 [InstanceEdit:8856137] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9640101] Orlic-Milacic, Marija, 2019-03-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK12 stimulates expression of DNA repair genes
output	[CandidateSet:6797713] BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes [Homo sapiens] [Reaction:6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes [Homo sapiens]
regulatedBy	[PositiveRegulation:6797711] Positive regulation by 'CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm]'
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861387] R-HSA-6797712.4
summation	[Summation:6797721] CDK12-mediated phosphorylation of the C-terminal domain (CTD...
(hasEvent)	[Pathway:6796648] TP53 Regulates Transcription of DNA Repair Genes [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777800] Update Tracker - [BlackBoxEvent:6797712] CDK12 stimulates expression of DNA repair genes - v69:[addLiteratureReference]
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