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Details on Person DMGDH:FAD oxidatively demethylates DMGLY to SARC

Class:IdReaction:6797653
_displayNameDMGDH:FAD oxidatively demethylates DMGLY to SARC
_doReleaseTRUE
_timestamp2026-01-20 16:22:29
authored[InstanceEdit:6797656] Jassal, Bijay, 2015-09-15
catalystActivity[CatalystActivity:6797654] dimethylglycine dehydrogenase activity of DMGDH:FAD [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:6797656] Jassal, Bijay, 2015-09-15
crossReference[DatabaseIdentifier:9979085] RHEA:52857
edited[InstanceEdit:6797656] Jassal, Bijay, 2015-09-15
input[SimpleEntity:6797923] DMGLY [mitochondrial matrix]
[SimpleEntity:9979086] THFpolyGlu [mitochondrial matrix]
[SimpleEntity:113596] FAD [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
internalReviewed[InstanceEdit:9979111] D'Eustachio, Peter, 2026-01-14
isChimericFALSE
literatureReference[LiteratureReference:9979078] Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant
[LiteratureReference:6797924] Structure and analysis of the human dimethylglycine dehydrogenase gene
[LiteratureReference:6797925] Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency
modified[InstanceEdit:6797677] Jassal, Bijay, 2015-09-15
[InstanceEdit:6797914] Jassal, Bijay, 2015-09-16
[InstanceEdit:6797960] Jassal, Bijay, 2015-09-16
[InstanceEdit:6798167] Jassal, Bijay, 2015-09-17
[InstanceEdit:6798189] Jassal, Bijay, 2015-09-17
[InstanceEdit:8851786] Jassal, Bijay, 2016-01-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9979091] D'Eustachio, Peter, 2026-01-14
[InstanceEdit:9979110] D'Eustachio, Peter, 2026-01-14
[InstanceEdit:9979656] D'Eustachio, Peter, 2026-01-20
nameDMGDH:FAD oxidatively demethylates DMGLY to SARC
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized (electron-transfer flavoprotein) + H(+) => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced (electron-transfer flavoprotein)
output[SimpleEntity:6797917] SARC [mitochondrial matrix]
[SimpleEntity:9979072] MeTHFpolyGlu [mitochondrial matrix]
[SimpleEntity:31649] FADH2 [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
[InstanceEdit:9979657] Hill, David P, 2026-01-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8860921] R-HSA-6797653.3
structureModified[InstanceEdit:9979091] D'Eustachio, Peter, 2026-01-14
summation[Summation:6797916] Mitochondrial dimethylglycine dehydrogenase (DMGDH) mediates...
(hasEvent)[Pathway:6798163] Choline catabolism [Homo sapiens]
(precedingEvent)[Reaction:6797913] SARDH:FAD oxidatively demethylates SARC to Gly [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984642] Update Tracker - [Reaction:6797653] DMGDH:FAD oxidatively demethylates DMGLY to SARC - v96:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
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