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Details on Person ASPG hydrolyses L-Asn to L-Asp

Class:IdReaction:6797627
_displayNameASPG hydrolyses L-Asn to L-Asp
_doReleaseTRUE
_timestamp2024-12-03 20:52:41
authored[InstanceEdit:6797639] Jassal, Bijay, 2015-09-15
catalystActivity[CatalystActivity:6797637] asparaginase activity of ASPG [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:6797639] Jassal, Bijay, 2015-09-15
crossReference[DatabaseIdentifier:9925770] RHEA:21017
edited[InstanceEdit:6797639] Jassal, Bijay, 2015-09-15
input[SimpleEntity:29642] L-Asn [cytosol]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
isChimericFALSE
literatureReference[LiteratureReference:6797646] Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine
modified[InstanceEdit:6797652] Jassal, Bijay, 2015-09-15
[InstanceEdit:8851786] Jassal, Bijay, 2016-01-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9925772] D'Eustachio, Peter, 2024-10-24
[InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31
[InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
[InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
nameASPG hydrolyses L-Asn to L-Asp
H2O + L-asparagine => L-aspartate + NH4(+)
negativePrecedingEvent[NegativePrecedingEvent:9930396] Futile Cycle: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
output[SimpleEntity:29448] L-Asp [cytosol]
[SimpleEntity:31633] NH4+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
[InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8860924] R-HSA-6797627.4
structureModified[InstanceEdit:9925772] D'Eustachio, Peter, 2024-10-24
summation[Summation:6797636] L-Asparaginases can catalyse the hydrolysis of L-asparagine ...
(hasEvent)[Pathway:8963693] Aspartate and asparagine metabolism [Homo sapiens]
(precedingEvent)[Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens]
[Reaction:6787757] PXLP-K333-GADL1 decarboxylates acidic AAs [Homo sapiens]
[NegativePrecedingEvent:9930400] Futile Cycle: ASPG hydrolyses L-Asn to L-Asp
(updatedInstance)[_UpdateTracker:9928416] Update Tracker - [Reaction:6797627] ASPG hydrolyses L-Asn to L-Asp - v91:[add_removeOutput]
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No pathways have been reviewed or authored by ASPG hydrolyses L-Asn to L-Asp (6797627)
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