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Details on Person Signal transducer and activator of transcription 3 (STAT3) i...

Class:Id	Summation:6797249
_displayName	Signal transducer and activator of transcription 3 (STAT3) i...
_timestamp	2015-09-14 14:00:48
created	[InstanceEdit:6797246] Jupe, Steve, 2015-09-07
literatureReference	[LiteratureReference:6789554] Stat3 regulates genes common to both wound healing and cancer [LiteratureReference:6789601] Evaluation of potential Stat3-regulated genes in human breast cancer [LiteratureReference:6789584] Identification of novel direct Stat3 target genes for control of growth and differentiation [LiteratureReference:6789583] The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins [LiteratureReference:6789995] Cooperation between STAT3 and c-jun suppresses Fas transcription
modified	[InstanceEdit:6797260] Jupe, Steve, 2015-09-07 [InstanceEdit:6797572] Jupe, Steve, 2015-09-14
text	Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes that are downregulated by STAT3 include the extracellular protein Tumor necrosis factor ligand superfamily member 6 (FASLG) (Ivanov et al. 2001).
(summation)	[BlackBoxEvent:6797245] Expression of FASLG [Homo sapiens]
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No pathways have been reviewed or authored by Signal transducer and activator of transcription 3 (STAT3) i... (6797249)