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Details on Person SGK1 phosphorylates MDM2

Class:IdReaction:6795460
_displayNameSGK1 phosphorylates MDM2
_doReleaseTRUE
_timestamp2020-02-24 15:16:15
authored[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity[CatalystActivity:6795452] protein serine/threonine kinase activity of p-T256,S422-SGK1 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:6795462] Orlic-Milacic, Marija, 2015-09-04
edited[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input[EntityWithAccessionedSequence:198644] MDM2 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:6795471] Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation
[LiteratureReference:6795454] Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway
modified[InstanceEdit:6806090] Orlic-Milacic, Marija, 2015-10-21
[InstanceEdit:8856342] Orlic-Milacic, Marija, 2016-02-09
[InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10
[InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10
[InstanceEdit:9676937] Orlic-Milacic, Marija, 2020-02-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSGK1 phosphorylates MDM2
output[EntityWithAccessionedSequence:198638] p-S166,S188-MDM2 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8860900] R-HSA-6795460.3
summation[Summation:6795459] SGK1 phosphorylates MDM2 at serine residues S166 and S188, r...
(hasEvent)[Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(precedingEvent)[Reaction:6793666] MDM2 translocates to the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by SGK1 phosphorylates MDM2 (6795460)