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Details on Person Spine-Associated RapGAP (SPAR) interacts with a PDZ-LIM doma...
| Class:Id | Summation:6794043 |
|---|---|
| _displayName | Spine-Associated RapGAP (SPAR) interacts with a PDZ-LIM doma... |
| _timestamp | 2018-04-13 17:33:47 |
| created | [InstanceEdit:6794080] Garapati, Phani Vijay, 2015-09-04 |
| literatureReference | [LiteratureReference:6794139] A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder [LiteratureReference:6794134] Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia [LiteratureReference:6794069] Positive association between PDLIM5 and schizophrenia in the Chinese Han population [LiteratureReference:6794140] Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage |
| modified | [InstanceEdit:9605546] Orlic-Milacic, Marija, 2018-04-13 |
| text | Spine-Associated RapGAP (SPAR) interacts with a PDZ-LIM domain family protein called PDZ and LIM domain 5 (PDLIM5), formerly known as Enigma Homolog (ENH). PDLIM5 is expressed postsynaptically in excitatory pyramidal neurons of the hippocampus and associates with SPAR protein in the brain. In hippocampal neurons, PDLIM5 promotes decreased dendritic spine size, opposite to the effect of SPAR overexpression that causes spine head enlargement. Single nucleotide polymorphisms in PDLIM5 have been associated with schizophrenia, depression, and bipolar disorder (Kato et al. 2005, Li et al. 2008, Liu et al. 2008), although the physiological functions of PDLIM5 are not well understood. |
| (summation) | [Reaction:6794354] NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 [Homo sapiens] [Reaction:6794358] Pdlim5 binds Spar [Rattus norvegicus] |
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No pathways have been reviewed or authored by Spine-Associated RapGAP (SPAR) interacts with a PDZ-LIM doma... (6794043)
