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Details on Person Homer proteins are closely related neuronal scaffolding mole...
| Class:Id | Summation:6794042 |
|---|---|
| _displayName | Homer proteins are closely related neuronal scaffolding mole... |
| _timestamp | 2015-09-04 16:04:12 |
| created | [InstanceEdit:6794080] Garapati, Phani Vijay, 2015-09-04 |
| literatureReference | [LiteratureReference:6794052] Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins [LiteratureReference:6794058] Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins [LiteratureReference:6794061] Homer: a protein that selectively binds metabotropic glutamate receptors [LiteratureReference:6794054] Overproduction of recombinant Trichoderma reesei cellulases by Aspergillus oryzae and their enzymatic properties |
| text | Homer proteins are closely related neuronal scaffolding molecules that selectively binds the C-terminus of group 1 metabotropic or heterotrimeric GTP-binding protein-linked glutamate receptors (mGluR1a and mGluR5) and are enriched at excitatory synapses (Brakeman et al. 1997, Xiao et al. 1998). Homer proteins contain an amino-terminal EVH1 domain followed by a rod-shaped coiled-coil domain. The EVH1 domain of Homer can bind the proline rich motifs in mGluRs and the inositol 1,4,5-trisphosphate (IP3) receptors, thereby linking these receptors in a signalling complex (Tu et al. 1998, 1999). |
| (summation) | [Reaction:6794355] Homer1,2,3 binds mGluR1a,5 [Homo sapiens] |
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No pathways have been reviewed or authored by Homer proteins are closely related neuronal scaffolding mole... (6794042)
