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Details on Person Signal transducer and activator of transcription 3 (STAT3) i...

Class:Id	Summation:6793988
_displayName	Signal transducer and activator of transcription 3 (STAT3) i...
_timestamp	2015-09-14 14:00:44
created	[InstanceEdit:6793965] Jupe, Steve, 2015-09-04
literatureReference	[LiteratureReference:6789554] Stat3 regulates genes common to both wound healing and cancer [LiteratureReference:6789601] Evaluation of potential Stat3-regulated genes in human breast cancer [LiteratureReference:6789584] Identification of novel direct Stat3 target genes for control of growth and differentiation [LiteratureReference:6789622] STAT3 Target Genes Relevant to Human Cancers [LiteratureReference:6789696] Signal transducer and activator of transcription 3 activates CCAAT enhancer-binding protein delta gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland [LiteratureReference:6789632] Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [LiteratureReference:6789676] STAT3 is required for the gp130-mediated full activation of the c-myc gene [LiteratureReference:6789579] Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis [LiteratureReference:6789593] Independent and cooperative activation of chromosomal c-fos promoter by STAT3 [LiteratureReference:6789641] Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells [LiteratureReference:6789619] Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate [LiteratureReference:6789703] TRIM8 regulates Nanog via Hsp90�-mediated nuclear translocation of STAT3 in embryonic stem cells [LiteratureReference:6789659] Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function [LiteratureReference:6789977] Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway [LiteratureReference:6789662] Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition [LiteratureReference:6789608] STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1 [LiteratureReference:6789657] Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells [LiteratureReference:6789752] Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3 [LiteratureReference:6789785] The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia [LiteratureReference:6789954] STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors [LiteratureReference:6789949] Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis [LiteratureReference:6789919] Transcriptional regulation of the junB promoter: analysis of STAT-mediated signal transduction
modified	[InstanceEdit:6797572] Jupe, Steve, 2015-09-14
text	Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes for nuclear proteins upregulated by STAT3 include CCAAT/enhancer-binding protein delta (CEBPD) (Hutt et al. 2000), B-cell lymphoma 6 protein (BCL6) (Reljic et al. 2000), Myc proto-oncogene protein (MYC) (Kiuchi et al. 1999, Bowman et al. 2001), Proto-oncogene c-Fos (FOS) (Yang et al. 2003), Hypoxia-inducible factor 1-alpha (HIF1A) (Niu et al. 2008), Transcription factor SOX-2 (SOX2) (Foshay & Gallicano 2008), the homeobox protein NANOG (Okumura et al. 2011), Twist-related protein 1 (TWIST1) (Lo et al. 2007, Cheng et al. 2008), Zinc finger E-box-binding homeobox 1 (ZEB1) (Xiong et al. 2012), POU domain, class 2, transcription factor 1 (POU2F1) (OCT1) (Wang et al. 2013), Baculoviral IAP repeat-containing protein 5 (BIRC5, Survivin) (Gritsko et al. 2006), G1/S-specific cyclin-D1 (CCND1) (Leslie et al. 2006), Serine/threonine-protein kinase PIM1 (Przanowski et al. 2014), Forkhead box protein O1 (FOXO1), FOXO3 (Oh et al. 2011), Nuclear receptor ROR-alpha (RORA), RORC, Basic leucine zipper transcriptional factor ATF-like (BATF) (Durant et al. 2010) and Transcription factor JUNB (Coffer et al. 1995).
(summation)	[BlackBoxEvent:6790036] Expression of STAT3-upregulated nuclear proteins [Homo sapiens]
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