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Details on Person Signal transducer and activator of transcription 3 (STAT3) i...

Class:IdSummation:6793972
_displayNameSignal transducer and activator of transcription 3 (STAT3) i...
_timestamp2021-07-07 14:48:58
created[InstanceEdit:6793965] Jupe, Steve, 2015-09-04
literatureReference[LiteratureReference:6789554] Stat3 regulates genes common to both wound healing and cancer
[LiteratureReference:6789601] Evaluation of potential Stat3-regulated genes in human breast cancer
[LiteratureReference:6789584] Identification of novel direct Stat3 target genes for control of growth and differentiation
[LiteratureReference:6789622] STAT3 Target Genes Relevant to Human Cancers
[LiteratureReference:6793963] STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells
[LiteratureReference:6789552] Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
[LiteratureReference:9704670] Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors
[LiteratureReference:9704684] Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein
modified[InstanceEdit:6797572] Jupe, Steve, 2015-09-14
[InstanceEdit:9710983] Shamovsky, Veronica, 2021-01-06
[InstanceEdit:9713622] Shamovsky, Veronica, 2021-01-27
[InstanceEdit:9736382] Shamovsky, Veronica, 2021-07-07
textSignal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014), including the mitochondrial outer membrane protein genes Apoptosis regulator BCL2 (Bhattacharya et al. 2005) and Bcl-2-like protein 1 (BCL2L1, Bcl-XL) (Catlett-Falcone et al. 1999).

Severe acute respiratory syndrome coronavirus type 1 (SARS-CoV-1) E protein was reported to induce apoptosis by sequestering anti-apoptotic BCL2L1 to membranes of the endoplasmic reticulum (ER) and Golgi, where viral E protein is located (Yang Y et al. 2005). Similar findings were reported for SARS-CoV-1 7a (Tan YX et al. 2007).

(summation)[BlackBoxEvent:6790025] Expression of BCL2, BCL2L1 [Homo sapiens]
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