Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Signal transducer and activator of transcription 3 (STAT3) i...

Class:Id	Summation:6793960
_displayName	Signal transducer and activator of transcription 3 (STAT3) i...
_timestamp	2015-09-14 14:00:34
created	[InstanceEdit:6793965] Jupe, Steve, 2015-09-04
literatureReference	[LiteratureReference:6789554] Stat3 regulates genes common to both wound healing and cancer [LiteratureReference:6789601] Evaluation of potential Stat3-regulated genes in human breast cancer [LiteratureReference:6789584] Identification of novel direct Stat3 target genes for control of growth and differentiation [LiteratureReference:6789622] STAT3 Target Genes Relevant to Human Cancers [LiteratureReference:6789602] Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor [LiteratureReference:6789732] Diverse effects of Stat1 on the regulation of hsp90alpha gene under heat shock [LiteratureReference:6789841] Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration [LiteratureReference:6789792] Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89 [LiteratureReference:6789782] The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways [LiteratureReference:6789795] Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways [LiteratureReference:6789946] STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 [LiteratureReference:6789949] Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis [LiteratureReference:6789977] Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
modified	[InstanceEdit:6797572] Jupe, Steve, 2015-09-14
text	Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes for cytoplasmic proteins upregulated by STAT3 include Suppressor of cytokine signaling 3 (SOCS3) (He et al. 2003), Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) (Becker et al. 2014), Heat shock protein HSP 90-alpha (HSP90AA1) (Chen et al. 2007), Fascin (FSCN1) (Snyder et al. 2011), Vimentin (VIM) (Wu et al. 2004), Rho-related GTP-binding protein RhoU (RHOU) (Schiavone et al. 2009), RAC-alpha serine/threonine-protein kinase (AKT1) (Xu et al. 2005), Cyclin-dependent kinase inhibitor 1 (CDKN1A) (Bellido et al. 1998), Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) (Abell et al. 2005), Signal transducer and activator of transcription 1 (STAT1) (Han et al. 2013), Interferon regulatory factor 4 (IRF4) (Durant et al. 2010) and Nitric oxide synthase, inducible (NOS2) (Lo et al. 2005).
(summation)	[BlackBoxEvent:6790041] Expression of STAT3-upregulated cytosolic proteins [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Signal transducer and activator of transcription 3 (STAT3) i... (6793960)