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Details on Person Box C/D snoRNP methylates ribonucleotides in pre-rRNA

Class:Id	Reaction:6793739
_displayName	Box C/D snoRNP methylates ribonucleotides in pre-rRNA
_doRelease	TRUE
_timestamp	2016-02-19 18:19:31
authored	[InstanceEdit:6793301] May, Bruce, 2015-09-01
catalystActivity	[CatalystActivity:6793713] O-methyltransferase activity of Box C/D snoRNP [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643409] O-methyltransferase activity of Box C/D snoRNP [nucleoplasm] Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6793711] May, Bruce, 2015-09-04
edited	[InstanceEdit:6793301] May, Bruce, 2015-09-01
goBiologicalProcess	[GO_BiologicalProcess:258833] rRNA 2'-O-methylation
input	[GenomeEncodedEntity:6793689] pre-rRNA [nucleoplasm] [Saccharomyces cerevisiae] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6793703] Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro [LiteratureReference:6793727] Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs [LiteratureReference:6793700] Sequence and structural elements of methylation guide snoRNAs essential for site-specific ribose methylation of pre-rRNA [LiteratureReference:6793709] Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis [LiteratureReference:6793688] Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability [LiteratureReference:6793712] A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability [LiteratureReference:6790814] A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP [LiteratureReference:6793707] Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast [LiteratureReference:6793745] Synthesis and assembly of the box C+D small nucleolar RNPs
modified	[InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8856927] May, Bruce, 2016-02-12 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Box C/D snoRNP methylates ribonucleotides in pre-rRNA
output	[GenomeEncodedEntity:6793746] pre-rRNA containing 2'-O-methylribonucleotides [nucleoplasm] [Saccharomyces cerevisiae] [SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30 [InstanceEdit:8856924] Sharma, Sunny, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:68322] Saccharomyces cerevisiae
stableIdentifier	[StableIdentifier:8860946] R-SCE-6793739.3
summation	[Summation:6793692] The NOP1 component of box C/D small nucleolar ribonucleoprot...
(inferredFrom)	[Reaction:6790907] Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides [Homo sapiens]
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