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Details on Person The WBSCR22:TRMT112 complex, homolog of the Bud23:Trm112 com...
| Class:Id | Summation:6793731 |
|---|---|
| _displayName | The WBSCR22:TRMT112 complex, homolog of the Bud23:Trm112 com... |
| _timestamp | 2015-12-12 04:15:18 |
| created | [InstanceEdit:6793711] May, Bruce, 2015-09-04 |
| modified | [InstanceEdit:6798735] May, Bruce, 2015-09-21 [InstanceEdit:8849108] May, Bruce, 2015-12-12 |
| text | The WBSCR22:TRMT112 complex, homolog of the Bud23:Trm112 complex in yeast (Ounap et al. 2013), methylates guanosine-1639 of 18S rRNA at the N(7) position of the guanine base (Haag et al. 2015, Zorbas et al. 2015). The WBSCR22:TRMT112 complex but not its methylase activity is required for efficient processing of precursor rRNA at site 2 and site 3 (Haag et al. 2015, Zorbas et al. 2015). Hemizygosity at the region containing WBSCR22 causes Williams-Beuren syndrome (Doll and Grzeschik 2001). |
| (summation) | [Reaction:6790982] WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 [Homo sapiens] |
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No pathways have been reviewed or authored by The WBSCR22:TRMT112 complex, homolog of the Bud23:Trm112 com... (6793731)
