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Details on Person Ubiquitinated TP53 translocates to the cytosol

Class:Id	Reaction:6793685
_displayName	Ubiquitinated TP53 translocates to the cytosol
_doRelease	TRUE
_timestamp	2016-07-28 15:24:42
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:6793686] Orlic-Milacic, Marija, 2015-09-03
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[Complex:3209186] PolyUb-TP53 Tetramer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6793677] An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 [LiteratureReference:6793680] The MDM2 RING-finger domain is required to promote p53 nuclear export
modified	[InstanceEdit:6795377] Orlic-Milacic, Marija, 2015-09-04 [InstanceEdit:8856288] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856346] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8932754] Orlic-Milacic, Marija, 2016-07-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitinated TP53 translocates to the cytosol
output	[Complex:8856287] PolyUb-TP53 Tetramer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:6804879] MDM2 ubiquitinates TP53 [Homo sapiens] [Reaction:5633460] MDM2 binds TP53 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860947] R-HSA-6793685.3
summation	[Summation:6795301] Upon MDM2-mediated ubiquitination, TP53 is exported from the...
(hasEvent)	[Pathway:69541] Stabilization of p53 [Homo sapiens] [Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782760] Update Tracker - [Reaction:6793685] Ubiquitinated TP53 translocates to the cytosol - v58:[modifyText]
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