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Details on Person MDM2 translocates to the nucleus

Class:Id	Reaction:6793666
_displayName	MDM2 translocates to the nucleus
_doRelease	TRUE
_timestamp	2016-02-19 18:19:32
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:6793664] Orlic-Milacic, Marija, 2015-09-03
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:198638] p-S166,S188-MDM2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6793667] A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
modified	[InstanceEdit:6793673] Orlic-Milacic, Marija, 2015-09-03 [InstanceEdit:6806090] Orlic-Milacic, Marija, 2015-10-21 [InstanceEdit:8856342] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MDM2 translocates to the nucleus
output	[EntityWithAccessionedSequence:6793669] p-S166,S188-MDM2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:198599] AKT phosphorylates MDM2 [Homo sapiens] [Reaction:198270] PDPK1 phosphorylates AKT at T308 [Homo sapiens] [Reaction:6795667] MDM2 translocates to the cytosol [Homo sapiens] [Reaction:6795460] SGK1 phosphorylates MDM2 [Homo sapiens] [Reaction:6795473] PDPK1 phosphorylates SGK1 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860948] R-HSA-6793666.2
summation	[Summation:6793672] AKT- or SGK1-phosphorylated MDM2 residues S166 and S188 are ...
(hasEvent)	[Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(precedingEvent)	[Reaction:6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 [Homo sapiens] [Reaction:6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 [Homo sapiens] [Reaction:6804741] MDM2 forms homo- or heterodimers [Homo sapiens] [Reaction:6804955] ATM phosphorylates MDM2 [Homo sapiens]
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