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Details on Person (CDK1,CDK2):CCNA phosphorylates MDM2 at T218

Class:Id	Reaction:6793661
_displayName	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
_doRelease	TRUE
_timestamp	2016-02-19 18:19:32
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6793658] cyclin-dependent protein serine/threonine kinase activity of CCNA:p-CDK1/2 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6793660] Orlic-Milacic, Marija, 2015-09-03
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[SimpleEntity:29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:6793669] p-S166,S188-MDM2 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:6793662] Cyclin a-CDK phosphorylation regulates MDM2 protein interactions
modified	[InstanceEdit:6793663] Orlic-Milacic, Marija, 2015-09-03 [InstanceEdit:6793670] Orlic-Milacic, Marija, 2015-09-03 [InstanceEdit:6804844] Orlic-Milacic, Marija, 2015-10-15 [InstanceEdit:6806090] Orlic-Milacic, Marija, 2015-10-21 [InstanceEdit:8856346] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
output	[EntityWithAccessionedSequence:6792862] p-S166,S188,T218-MDM2 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:6793666] MDM2 translocates to the nucleus [Homo sapiens] [Reaction:198599] AKT phosphorylates MDM2 [Homo sapiens] [Reaction:6795460] SGK1 phosphorylates MDM2 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860949] R-HSA-6793661.2
summation	[Summation:6793659] CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates ...
(hasEvent)	[Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(precedingEvent)	[Reaction:6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 [Homo sapiens]
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No pathways have been reviewed or authored by (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (6793661)