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Details on Person LIAS synthesizes lipoyl-GCSH
Class:Id Reaction:6793591 _displayName LIAS synthesizes lipoyl-GCSH _doRelease TRUE _timestamp 2024-02-27 08:32:44 authored [InstanceEdit:6793592] Jassal, Bijay, 2015-09-02 catalystActivity [CatalystActivity:6793618] lipoate synthase activity of LIAS:2(4Fe-4S) [mitochondrial matrix] compartment [Compartment:5460] mitochondrial matrix created [InstanceEdit:6793592] Jassal, Bijay, 2015-09-02 crossReference [DatabaseIdentifier:9857619] RHEA:16586 edited [InstanceEdit:6793592] Jassal, Bijay, 2015-09-02 input [EntityWithAccessionedSequence:6793586] octanoyl-K107-GCSH [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162265] AdoMet [mitochondrial matrix] [SimpleEntity:2162265] AdoMet [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [Complex:6793623] LIAS:2(4Fe-4S) [mitochondrial matrix] [Homo sapiens] [Complex:2395509] FDX1 (ox.) [mitochondrial matrix] [Homo sapiens] [Complex:2395509] FDX1 (ox.) [mitochondrial matrix] [Homo sapiens] internalReviewed [InstanceEdit:9859177] D'Eustachio, Peter, 2024-01-16 isChimeric FALSE literatureReference [LiteratureReference:6793624] Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria [LiteratureReference:6793615] Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation [LiteratureReference:9857790] Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells [LiteratureReference:9857776] In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1 [LiteratureReference:9857784] FDX1 regulates cellular protein lipoylation through direct binding to LIAS [LiteratureReference:9857780] Progress in the Enzymology of the Mitochondrial Diseases of Lipoic Acid Requiring Enzymes modified [InstanceEdit:6793612] Jassal, Bijay, 2015-09-02 [InstanceEdit:6793626] Jassal, Bijay, 2015-09-02 [InstanceEdit:6797579] Jassal, Bijay, 2015-09-14 [InstanceEdit:6797700] Jassal, Bijay, 2015-09-15 [InstanceEdit:8855124] D'Eustachio, Peter, 2016-02-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857622] Stephan, Ralf, 2024-01-08 [InstanceEdit:9857777] Stephan, Ralf, 2024-01-09 [InstanceEdit:9858047] Stephan, Ralf, 2024-01-10 [InstanceEdit:9859176] Stephan, Ralf, 2024-01-16 [InstanceEdit:9859570] Stephan, Ralf, 2024-01-21 [InstanceEdit:9863111] Stephan, Ralf, 2024-02-27 name LIAS synthesizes lipoyl-GCSH output [EntityWithAccessionedSequence:6793611] Lipo-K107-GCSH [mitochondrial matrix] [Homo sapiens] [SimpleEntity:6793613] 5dAde [mitochondrial matrix] [SimpleEntity:6793613] 5dAde [mitochondrial matrix] [SimpleEntity:379705] L-Met [mitochondrial matrix] [SimpleEntity:379705] L-Met [mitochondrial matrix] [SimpleEntity:1655881] H2S [mitochondrial matrix] [SimpleEntity:1655881] H2S [mitochondrial matrix] [SimpleEntity:9857621] Fe3+ [mitochondrial matrix] [SimpleEntity:9857621] Fe3+ [mitochondrial matrix] [SimpleEntity:9857621] Fe3+ [mitochondrial matrix] [SimpleEntity:9857621] Fe3+ [mitochondrial matrix] [Complex:2395507] FDX1 (red.) [mitochondrial matrix] [Homo sapiens] [Complex:2395507] FDX1 (red.) [mitochondrial matrix] [Homo sapiens] [Complex:9857620] LIAS:4Fe-4S [mitochondrial matrix] [Homo sapiens] precedingEvent
previousReviewStatus [ReviewStatus:9821385] four stars releaseDate 2015-12-15 releaseStatus NEW reviewed [InstanceEdit:6797578] D'Eustachio, Peter, 2015-09-14 [InstanceEdit:9861443] Hill, David P, 2024-02-20 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:6812478] R-HSA-6793591.4 structureModified [InstanceEdit:9857622] Stephan, Ralf, 2024-01-08 summation [Summation:6793620] Mitochondrial lipoyl synthase (LIAS) mediates the radical-me... (hasEvent) [Pathway:9857492] Protein lipoylation [Homo sapiens] (precedingEvent) [Reaction:6792572] LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST [Homo sapiens] [Reaction:9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT [Homo sapiens] (updatedInstance) [_UpdateTracker:9864001] Update Tracker - [Reaction:6793591] LIAS synthesizes lipoyl-GCSH - v88:[addLiteratureReference, addOutput, add_removeInput, modifyText]
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