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Details on Person MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine

Class:Id	Reaction:6793127
_displayName	MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine
_doRelease	TRUE
_timestamp	2016-05-19 16:45:22
authored	[InstanceEdit:6793121] May, Bruce, 2015-08-30
catalystActivity	[CatalystActivity:6793126] rRNA (uridine-2'-O-ribose)-methyltransferase activity of FTSJ2 [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643440] rRNA (uridine-2'-O-)-methyltransferase activity of FTSJ2 [mitochondrial matrix] Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA)
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6793125] May, Bruce, 2015-08-30
edited	[InstanceEdit:6793121] May, Bruce, 2015-08-30
goBiologicalProcess	[GO_BiologicalProcess:258833] rRNA 2'-O-methylation
input	[EntityWithAccessionedSequence:6792998] 16S rRNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162265] AdoMet [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:6793115] Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA) [LiteratureReference:6793298] MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome [LiteratureReference:6793118] Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid
modified	[InstanceEdit:6793301] May, Bruce, 2015-09-01 [InstanceEdit:6798649] May, Bruce, 2015-09-21 [InstanceEdit:8855124] D'Eustachio, Peter, 2016-02-01 [InstanceEdit:8868774] May, Bruce, 2016-04-25 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine
output	[EntityWithAccessionedSequence:6793117] 16S rRNA containing 2'-O-methylU-1369 [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix]
precedingEvent	[Reaction:8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868767] Bogenhagen, Daniel F, 2016-04-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873244] R-HSA-6793127.4
summation	[Summation:6798647] MRM2 (FTSJ2) located in foci near mitochondrial nucleoids (L...
(hasEvent)	[Pathway:6793080] rRNA modification in the mitochondrion [Homo sapiens]
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