Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937

Class:Id	Reaction:6793066
_displayName	TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937
_doRelease	TRUE
_timestamp	2016-05-19 16:45:21
authored	[InstanceEdit:6793024] May, Bruce, 2015-08-28
catalystActivity	[CatalystActivity:6793073] rRNA (adenine-N6,N6-)-dimethyltransferase activity of TFB1M [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643244] rRNA (adenine-N6,N6-)-dimethyltransferase activity of TFB1M [mitochondrial matrix] Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6793083] May, Bruce, 2015-08-29
edited	[InstanceEdit:6793024] May, Bruce, 2015-08-28
input	[EntityWithAccessionedSequence:6792974] 12S rRNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162265] AdoMet [mitochondrial matrix] [SimpleEntity:2162265] AdoMet [mitochondrial matrix] [SimpleEntity:2162265] AdoMet [mitochondrial matrix] [SimpleEntity:2162265] AdoMet [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:163224] A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine [LiteratureReference:163225] Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop [LiteratureReference:6793079] Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation [LiteratureReference:6793300] Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis [LiteratureReference:6793294] Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness [LiteratureReference:5210025] Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness [LiteratureReference:5210047] Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome [LiteratureReference:6807387] Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1 [LiteratureReference:8868768] Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing
modified	[InstanceEdit:6793301] May, Bruce, 2015-09-01 [InstanceEdit:6798649] May, Bruce, 2015-09-21 [InstanceEdit:6803013] May, Bruce, 2015-10-04 [InstanceEdit:6807399] May, Bruce, 2015-11-01 [InstanceEdit:8855124] D'Eustachio, Peter, 2016-02-01 [InstanceEdit:8868774] May, Bruce, 2016-04-25 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937
output	[EntityWithAccessionedSequence:6793060] 12S rRNA containing 6-dimethylA-936,937 [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix]
precedingEvent	[Reaction:8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868767] Bogenhagen, Daniel F, 2016-04-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873241] R-HSA-6793066.4
summation	[Summation:6798642] TFB1M transfers methyl groups from S-adenosylmethionine to t...
(hasEvent)	[Pathway:6793080] rRNA modification in the mitochondrion [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 (6793066)