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Details on Person NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841

Class:Id	Reaction:6793057
_displayName	NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841
_doRelease	TRUE
_timestamp	2016-05-19 16:45:21
authored	[InstanceEdit:6793024] May, Bruce, 2015-08-28
catalystActivity	[CatalystActivity:6793074] rRNA (cytosine-C5-)-methyltransferase activity of MTERF4:NSUN4 [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643079] rRNA (cytosine-C5-)-methyltransferase activity of MTERF4:NSUN4 [mitochondrial matrix] MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6793083] May, Bruce, 2015-08-29
edited	[InstanceEdit:6793024] May, Bruce, 2015-08-28
goBiologicalProcess	[GO_BiologicalProcess:161509] rRNA methylation
input	[EntityWithAccessionedSequence:6792974] 12S rRNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162265] AdoMet [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:6793071] MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome [LiteratureReference:6793064] Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis [LiteratureReference:6793070] Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification
modified	[InstanceEdit:6798649] May, Bruce, 2015-09-21 [InstanceEdit:8855124] D'Eustachio, Peter, 2016-02-01 [InstanceEdit:8868774] May, Bruce, 2016-04-25 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841
output	[EntityWithAccessionedSequence:6793078] 12S rRNA containing 5-methylC-841 [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix]
precedingEvent	[Reaction:8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8868767] Bogenhagen, Daniel F, 2016-04-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873242] R-HSA-6793057.4
summation	[Summation:6798646] MTERF4 forms a complex with NSUN4 (Camara et al. 2011, Spahr...
(hasEvent)	[Pathway:6793080] rRNA modification in the mitochondrion [Homo sapiens]
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No pathways have been reviewed or authored by NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 (6793057)