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Details on Person KAT5 acetylates ATM at shortened telomeres

Class:Id	Reaction:6792712
_displayName	KAT5 acetylates ATM at shortened telomeres
_doRelease	TRUE
_timestamp	2015-10-27 19:02:34
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:6792704] acetyltransferase activity of Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6792702] Orlic-Milacic, Marija, 2015-08-25
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:6792641] Orlic-Milacic, Marija, 2015-08-25
input	[SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [Complex:5682021] Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5682041] A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM [LiteratureReference:5682032] DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity [LiteratureReference:5682049] Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60 [LiteratureReference:5682136] HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response [LiteratureReference:6792708] Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity
modified	[InstanceEdit:6792740] Orlic-Milacic, Marija, 2015-08-26 [InstanceEdit:6806898] Orlic-Milacic, Marija, 2015-10-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	KAT5 acetylates ATM at shortened telomeres
output	[SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [Complex:6792710] Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5682018] MRN complex bound to shortened telomeres recruits ATM [Homo sapiens] [Reaction:5682020] MRN complex binds shortened telomeres [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6806897] Du, Fengxia, 2015-09-16 [InstanceEdit:6806895] Sun, Yingli, 2015-09-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797010] R-HSA-6792712.3
summation	[Summation:6792701] The histone acetyltransferase Tip60 (KAT5), in addition to f...
(hasEvent)	[Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence [Homo sapiens] [Pathway:9672999] ALT via HRR [Homo sapiens]
(precedingEvent)	[Reaction:5682026] MRN bound to shortened telomeres activates ATM [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783860] Update Tracker - [Reaction:6792712] KAT5 acetylates ATM at shortened telomeres - v55:[modifyText]
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No pathways have been reviewed or authored by KAT5 acetylates ATM at shortened telomeres (6792712)