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Details on Person LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST

Class:IdReaction:6792572
_displayNameLIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST
_doReleaseTRUE
_timestamp2024-02-27 08:32:54
authored[InstanceEdit:6792577] Jassal, Bijay, 2015-08-25
catalystActivity[CatalystActivity:6792625] lipoyltransferase activity of LIPT1 [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:6792577] Jassal, Bijay, 2015-08-25
edited[InstanceEdit:6792577] Jassal, Bijay, 2015-08-25
input[EntityWithAccessionedSequence:6793611] Lipo-K107-GCSH [mitochondrial matrix] [Homo sapiens]
[DefinedSet:6792579] DBT/DLST [mitochondrial matrix] [Homo sapiens]
internalReviewed[InstanceEdit:9859177] D'Eustachio, Peter, 2024-01-16
isChimericFALSE
literatureReference[LiteratureReference:6792622] Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene
[LiteratureReference:6792624] Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase
[LiteratureReference:6797535] Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes
[LiteratureReference:9857803] Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes
[LiteratureReference:9857798] Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
modified[InstanceEdit:6792635] Jassal, Bijay, 2015-08-25
[InstanceEdit:6792640] Jassal, Bijay, 2015-08-25
[InstanceEdit:6793592] Jassal, Bijay, 2015-09-02
[InstanceEdit:6793629] Jassal, Bijay, 2015-09-02
[InstanceEdit:6793630] Jassal, Bijay, 2015-09-02
[InstanceEdit:6793634] Jassal, Bijay, 2015-09-02
[InstanceEdit:6797540] Jassal, Bijay, 2015-09-14
[InstanceEdit:6797579] Jassal, Bijay, 2015-09-14
[InstanceEdit:6797700] Jassal, Bijay, 2015-09-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9857795] Stephan, Ralf, 2024-01-09
[InstanceEdit:9858047] Stephan, Ralf, 2024-01-10
[InstanceEdit:9858750] Stephan, Ralf, 2024-01-14
[InstanceEdit:9859176] Stephan, Ralf, 2024-01-16
[InstanceEdit:9859570] Stephan, Ralf, 2024-01-21
[InstanceEdit:9863111] Stephan, Ralf, 2024-02-27
nameLIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST
output[DefinedSet:6792580] Lipoylated DBT/DLST [mitochondrial matrix] [Homo sapiens]
[EntityWithAccessionedSequence:5693951] GCSH [mitochondrial matrix] [Homo sapiens]
precedingEvent
releaseDate2015-12-15
releaseStatusNEW
reviewed[InstanceEdit:6797578] D'Eustachio, Peter, 2015-09-14
[InstanceEdit:9861443] Hill, David P, 2024-02-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6812476] R-HSA-6792572.3
summation[Summation:6792630] Mitochondrial lipoyltransferase 1 (LIPT1) catalyses the tran...
(hasEvent)[Pathway:9857492] Protein lipoylation [Homo sapiens]
(precedingEvent)[Reaction:6793590] LIPT2 transfers octanoyl group to GCSH [Homo sapiens]
(updatedInstance)[_UpdateTracker:9864348] Update Tracker - [Reaction:6792572] LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST - v88:[addLiteratureReference, modifyText]
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