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Details on Person 28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm]

Class:IdComplex:6791568
_displayName28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm]
_timestamp2016-02-19 18:12:23
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:6791519] May, Bruce, 2015-08-21
hasComponent
isChimericFALSE
literatureReference[LiteratureReference:6791558] LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis
[LiteratureReference:6791150] Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex
[LiteratureReference:6791144] Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit
[LiteratureReference:6791153] Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation
[LiteratureReference:6791154] The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing
modified[InstanceEdit:8855037] May, Bruce, 2016-01-30
name28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8859023] R-HSA-6791568.1
(input)[BlackBoxEvent:6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA [Homo sapiens]
(output)[BlackBoxEvent:6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA [Homo sapiens]
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No pathways have been reviewed or authored by 28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (6791568)
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