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Details on Person TP53 stimulates APAF1 gene expression

Class:Id	BlackBoxEvent:6791348
_displayName	TP53 stimulates APAF1 gene expression
_doRelease	TRUE
_timestamp	2016-02-19 18:22:36
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:6791353] Orlic-Milacic, Marija, 2015-08-20
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:6791347] APAF1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6791355] APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis [LiteratureReference:6791361] Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
modified	[InstanceEdit:6791362] Orlic-Milacic, Marija, 2015-08-20 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809233] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810434] Orlic-Milacic, Marija, 2015-11-16 [InstanceEdit:6810437] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856077] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates APAF1 gene expression
output	[EntityWithAccessionedSequence:50099] APAF1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:6791349] TP53 binds the APAF1 gene promoter [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:6791346] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:APAF1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642899] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:APAF1 Gene [nucleoplasm]' APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861401] R-HSA-6791348.4
summation	[Summation:6791359] Once bound to the p53 response element in the promoter of th...
(hasEvent)	[Pathway:6803207] TP53 Regulates Transcription of Caspase Activators and Caspases [Homo sapiens]
(precedingEvent)	[Reaction:114254] CYCS binds to APAF1 [Homo sapiens]
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No pathways have been reviewed or authored by TP53 stimulates APAF1 gene expression (6791348)