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Details on Person 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA

Class:Id	BlackBoxEvent:6791227
_displayName	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA
_doRelease	TRUE
_timestamp	2016-11-19 09:02:41
authored	[InstanceEdit:6791012] May, Bruce, 2015-08-16
catalystActivity	[CatalystActivity:6791580] 5'-3' RNA exonuclease activity of XRN2 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643089] 5'-3' RNA exonuclease activity of XRN2 [nucleoplasm] Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6791220] May, Bruce, 2015-08-19
edited	[InstanceEdit:6791012] May, Bruce, 2015-08-16
input	[Complex:6791184] 47S pre-rRNA:SSU processome [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790853] The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA [LiteratureReference:6790633] NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing [LiteratureReference:6791152] Defects in 18 S or 28 S rRNA processing activate the p53 pathway [LiteratureReference:6791140] Nucleolin functions in the first step of ribosomal RNA processing [LiteratureReference:6791178] The first pre-rRNA-processing event occurs in a large complex: analysis by gel retardation, sedimentation, and UV cross-linking [LiteratureReference:6790852] A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis [LiteratureReference:6790820] A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4 [LiteratureReference:6797214] Isolation and proteomic characterization of the major proteins of the nucleolin-binding ribonucleoprotein complexes [LiteratureReference:6791149] Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [LiteratureReference:6797232] 5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decay [LiteratureReference:6807329] Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit
modified	[InstanceEdit:6797242] May, Bruce, 2015-09-06 [InstanceEdit:6807334] May, Bruce, 2015-10-31 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8864146] May, Bruce, 2016-03-12 [InstanceEdit:8949091] May, Bruce, 2016-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA
output	[Complex:6791211] 45S pre-rRNA:SSU processome [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:74992] Dissociation of PTRF:RNA Polymerase I:pre-rRNA complex [Homo sapiens] [Reaction:74993] PTRF binds the paused RNA Polymerase I complex [Homo sapiens]
regulatedBy	[PositiveRegulation:8948998] Positive regulation by 'NOL11 [nucleoplasm]' [Requirement:8949001] Requirement by 'UTPA complex [nucleoplasm]' [PositiveRegulation:8949004] Positive regulation by 'UTPC complex [nucleoplasm]' [Requirement:8949023] Requirement by 'NCL [nucleoplasm]' [Requirement:8949031] Requirement by 'UTP18 [nucleoplasm]' [Requirement:8949042] Requirement by 'SKIV2L2 [nucleoplasm]'
regulationReference	[RegulationReference:9641350] Requirement by 'UTPA complex [nucleoplasm]' The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA [RegulationReference:9641559] Positive regulation by 'UTPC complex [nucleoplasm]' Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit [RegulationReference:9642253] Positive regulation by 'NOL11 [nucleoplasm]' NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing [RegulationReference:9642567] Requirement by 'SKIV2L2 [nucleoplasm]' The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA [RegulationReference:9642666] Requirement by 'NCL [nucleoplasm]' Isolation and proteomic characterization of the major proteins of the nucleolin-binding ribonucleoprotein complexes [RegulationReference:9642972] Requirement by 'UTP18 [nucleoplasm]' Defects in 18 S or 28 S rRNA processing activate the p53 pathway
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861397] R-HSA-6791227.6
summation	[Summation:6791225] Unknown nucleases concomitantly cleave the 47S precursor rRN...
(hasEvent)	[Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:6791228] 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA [Homo sapiens] [BlackBoxEvent:9935837] The TRAMP:RNA exosome oligoadenylates pre-rRNA 5' external transcribed spacer (5'ETS) fragment [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781904] Update Tracker - [BlackBoxEvent:6791227] 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA - v60:[addRegulator]
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