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Details on Person 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA

Class:Id	BlackBoxEvent:6791222
_displayName	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA
_doRelease	TRUE
_timestamp	2016-11-19 09:01:39
authored	[InstanceEdit:6791012] May, Bruce, 2015-08-16
catalystActivity	[CatalystActivity:6791508] 3'-5'-RNA exonuclease activity of EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6791220] May, Bruce, 2015-08-19
edited	[InstanceEdit:6791012] May, Bruce, 2015-08-16
input	[Complex:6791199] 21S pre-rRNA:SSU processome [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6791149] Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [LiteratureReference:6791523] Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA [LiteratureReference:6791579] Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals
modified	[InstanceEdit:6791583] May, Bruce, 2015-08-21 [InstanceEdit:6797242] May, Bruce, 2015-09-06 [InstanceEdit:8849108] May, Bruce, 2015-12-12 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8949091] May, Bruce, 2016-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA
output	[Complex:6791187] 18SE pre-rRNA:SSU processome [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:6791221] 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA [Homo sapiens] [BlackBoxEvent:6791228] 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA [Homo sapiens]
regulatedBy	[Requirement:8948995] Requirement by 'EXOSC5 [nucleoplasm]' [Requirement:8949021] Requirement by 'SKIV2L2 [nucleoplasm]' [Requirement:8949033] Requirement by 'EXOSC10 [nucleoplasm]'
regulationReference	[RegulationReference:9641243] Requirement by 'EXOSC10 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [RegulationReference:9641425] Requirement by 'SKIV2L2 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [RegulationReference:9641997] Requirement by 'EXOSC5 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861392] R-HSA-6791222.5
summation	[Summation:6797237] An unknown endonuclease in the nucleolus cleaves at site E (...
(hasEvent)	[Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781572] Update Tracker - [BlackBoxEvent:6791222] 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA - v60:[addRegulator]
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