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Details on Person 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA

Class:Id	BlackBoxEvent:6791218
_displayName	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
_doRelease	TRUE
_timestamp	2020-02-10 12:02:34
authored	[InstanceEdit:6791012] May, Bruce, 2015-08-16
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:6791220] May, Bruce, 2015-08-19
edited	[InstanceEdit:6791012] May, Bruce, 2015-08-16
input	[Complex:6791568] 28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6791506] C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [LiteratureReference:6791534] The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L [LiteratureReference:6799479] ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis [LiteratureReference:8878865] Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing
modified	[InstanceEdit:6791583] May, Bruce, 2015-08-21 [InstanceEdit:6798649] May, Bruce, 2015-09-21 [InstanceEdit:6799481] May, Bruce, 2015-09-25 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8878870] May, Bruce, 2016-07-13 [InstanceEdit:8949091] May, Bruce, 2016-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9676149] May, Bruce, 2020-02-10 [InstanceEdit:9676150] May, Bruce, 2020-02-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
output	[Complex:72499] 60S ribosomal complex [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA [Homo sapiens] [BlackBoxEvent:6791228] 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA [Homo sapiens]
regulatedBy	[Requirement:8949002] Requirement by 'C1D [nucleoplasm]' [Requirement:8949010] Requirement by 'SKIV2L2 [nucleoplasm]' [Requirement:8949014] Requirement by 'DIS3 [nucleoplasm]' [Requirement:8949034] Requirement by 'MPHOSPH6 [nucleoplasm]' [Requirement:8949040] Requirement by 'EXOSC10 [nucleoplasm]' [Requirement:9676147] Requirement by 'ERI1 [nucleoplasm]' [Requirement:9676148] Requirement by 'ISG20L2 [nucleoplasm]'
regulationReference	[RegulationReference:9641313] Requirement by 'MPHOSPH6 [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [RegulationReference:9641467] Requirement by 'EXOSC10 [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [RegulationReference:9641573] Requirement by 'DIS3 [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [RegulationReference:9641616] Requirement by 'C1D [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [RegulationReference:9642638] Requirement by 'SKIV2L2 [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861394] R-HSA-6791218.7
summation	[Summation:6798644] The 12S pre-rRNA is nucleolytically cleaved to yield 5.8S rR...
(hasEvent)	[Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777183] Update Tracker - [BlackBoxEvent:6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - v72:[addRegulator, removeCatalystActivity] [_UpdateTracker:9781694] Update Tracker - [BlackBoxEvent:6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - v60:[addRegulator] [_UpdateTracker:9782951] Update Tracker - [BlackBoxEvent:6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - v58:[addCatalystActivity, addLiteratureReference, modifyText]
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