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Details on Person DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851

Class:Id	Reaction:6790994
_displayName	DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851
_doRelease	TRUE
_timestamp	2016-11-19 09:02:57
authored	[InstanceEdit:6790955] May, Bruce, 2015-08-15
catalystActivity	[CatalystActivity:6790970] rRNA (adenine-N6,N6-)-dimethyltransferase activity of DIMT1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643093] rRNA (adenine-N6,N6-)-dimethyltransferase activity of DIMT1 [nucleoplasm] The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6790964] May, Bruce, 2015-08-16
edited	[InstanceEdit:6790955] May, Bruce, 2015-08-15
goBiologicalProcess	[GO_BiologicalProcess:161509] rRNA methylation
input	[GenomeEncodedEntity:6790998] pre-rRNA containing 7-methylG-1639 [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790968] The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
modified	[InstanceEdit:6797242] May, Bruce, 2015-09-06 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8856927] May, Bruce, 2016-02-12 [InstanceEdit:8858394] May, Bruce, 2016-02-19 [InstanceEdit:8949091] May, Bruce, 2016-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851
output	[GenomeEncodedEntity:6791006] 21S pre-rRNA containing 7-methylG-1639, 6-dimethylA-1850,1851 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:6790982] WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 [Homo sapiens]
regulatedBy	[Requirement:8949037] Requirement by 'PNO1 [nucleoplasm]'
regulationReference	[RegulationReference:9642606] Requirement by 'PNO1 [nucleoplasm]' The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30 [InstanceEdit:8856924] Sharma, Sunny, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860956] R-HSA-6790994.5
summation	[Summation:6797238] DIMT1 (DIMT1L) dimethylates the N(6) position of adenosine-1...
(hasEvent)	[Pathway:6790901] rRNA modification in the nucleus and cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781899] Update Tracker - [Reaction:6790994] DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 - v60:[addRegulator]
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