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Details on Person NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842

Class:Id	BlackBoxEvent:6790987
_displayName	NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842
_doRelease	TRUE
_timestamp	2016-02-19 18:22:37
authored	[InstanceEdit:6790955] May, Bruce, 2015-08-15
catalystActivity	[CatalystActivity:6790978] N-acetyltransferase activity of NAT10:THUMPD1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643084] N-acetyltransferase activity of NAT10:THUMPD1 [nucleoplasm] Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:6790964] May, Bruce, 2015-08-16
edited	[InstanceEdit:6790955] May, Bruce, 2015-08-15
input	[SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:74978] nascent pre-rRNA transcript [nucleoplasm] [Homo sapiens] [SimpleEntity:113560] Ac-CoA [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790969] Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA) [LiteratureReference:6790993] Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1
modified	[InstanceEdit:6792486] May, Bruce, 2015-08-24 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8856927] May, Bruce, 2016-02-12 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842
output	[GenomeEncodedEntity:6790985] 18SE pre-rRNA containing 4-acetylcytidine-1377,1842 [nucleoplasm] [Homo sapiens] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113550] Pi [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30 [InstanceEdit:8856924] Sharma, Sunny, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861403] R-HSA-6790987.3
summation	[Summation:6791005] NAT10 transfers an acetyl group from acetyl coenzyme A to th...
(hasEvent)	[Pathway:6790901] rRNA modification in the nucleus and cytosol [Homo sapiens]
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No pathways have been reviewed or authored by NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842 (6790987)