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Details on Person WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639

Class:Id	Reaction:6790982
_displayName	WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639
_doRelease	TRUE
_timestamp	2016-02-19 18:19:35
authored	[InstanceEdit:6790955] May, Bruce, 2015-08-15
catalystActivity	[CatalystActivity:6790997] rRNA (guanine-N7-)-methyltransferase activity of WBSCR22:TRIMT112 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643818] rRNA (guanine-N7-)-methyltransferase activity of WBSCR22:TRIMT112 [nucleoplasm] The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6790964] May, Bruce, 2015-08-16
edited	[InstanceEdit:6790955] May, Bruce, 2015-08-15
goBiologicalProcess	[GO_BiologicalProcess:161509] rRNA methylation
input	[SimpleEntity:77087] AdoMet [nucleoplasm] [GenomeEncodedEntity:8856933] pre-rRNA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790968] The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis [LiteratureReference:6790972] WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA [LiteratureReference:6798729] The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells [LiteratureReference:8849106] Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome
modified	[InstanceEdit:6792486] May, Bruce, 2015-08-24 [InstanceEdit:6793747] May, Bruce, 2015-09-04 [InstanceEdit:6798735] May, Bruce, 2015-09-21 [InstanceEdit:8849108] May, Bruce, 2015-12-12 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8856936] May, Bruce, 2016-02-12 [InstanceEdit:8858394] May, Bruce, 2016-02-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639
output	[GenomeEncodedEntity:6790998] pre-rRNA containing 7-methylG-1639 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30 [InstanceEdit:8856924] Sharma, Sunny, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860957] R-HSA-6790982.3
summation	[Summation:6793731] The WBSCR22:TRMT112 complex, homolog of the Bud23:Trm112 com...
(hasEvent)	[Pathway:6790901] rRNA modification in the nucleus and cytosol [Homo sapiens]
(precedingEvent)	[Reaction:6790994] DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 [Homo sapiens]
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No pathways have been reviewed or authored by WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 (6790982)