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Details on Person EMG1 of the SSU processome methylates pseudouridine-1191 of 18S rRNA yielding N(1)-methylpseudouridine-1191

Class:Id	Reaction:6790936
_displayName	EMG1 of the SSU processome methylates pseudouridine-1191 of 18S rRNA yielding N(1)-methylpseudouridine-1191
_doRelease	TRUE
_timestamp	2016-02-19 18:19:35
authored	[InstanceEdit:6790909] May, Bruce, 2015-08-15
catalystActivity	[CatalystActivity:6790950] rRNA (pseudouridine) methyltransferase activity of SSU Processome [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643315] rRNA (pseudouridine) methyltransferase activity of SSU Processome [nucleoplasm] Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6790913] May, Bruce, 2015-08-15
edited	[InstanceEdit:6790909] May, Bruce, 2015-08-15
goBiologicalProcess	[GO_BiologicalProcess:161509] rRNA methylation
input	[GenomeEncodedEntity:6790953] pre-rRNA containing pseudoU-1191 [nucleoplasm] [Saccharomyces cerevisiae] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790919] The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA [LiteratureReference:6790914] Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis [LiteratureReference:6790830] The small-subunit processome is a ribosome assembly intermediate
modified	[InstanceEdit:6793747] May, Bruce, 2015-09-04 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EMG1 of the SSU processome methylates pseudouridine-1191 of 18S rRNA yielding N(1)-methylpseudouridine-1191
output	[GenomeEncodedEntity:6790915] 18SE pre-rRNA containing 1-methylpseudoU-1191 [nucleoplasm] [Saccharomyces cerevisiae] [SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:68322] Saccharomyces cerevisiae
stableIdentifier	[StableIdentifier:8860958] R-SCE-6790936.3
summation	[Summation:6793736] EMG1 (NEP1) methylates a pseudouridine residue in precursor ...
(inferredFrom)	[Reaction:6790906] EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 [Homo sapiens]
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