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Details on Person Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides

Class:Id	Reaction:6790907
_displayName	Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides
_doRelease	TRUE
_timestamp	2016-02-19 18:19:34
authored	[InstanceEdit:6790903] May, Bruce, 2015-08-12
catalystActivity	[CatalystActivity:6790908] O-methyltransferase activity of Box C/D snoRNP [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6790904] May, Bruce, 2015-08-15
edited	[InstanceEdit:6790903] May, Bruce, 2015-08-12
goBiologicalProcess	[GO_BiologicalProcess:258833] rRNA 2'-O-methylation
inferredFrom	[Reaction:6793739] Box C/D snoRNP methylates ribonucleotides in pre-rRNA [Saccharomyces cerevisiae]
input	[EntityWithAccessionedSequence:74978] nascent pre-rRNA transcript [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790681] snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs [LiteratureReference:6790814] A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP [LiteratureReference:6790999] Eukaryotic ribosomal RNA: the recent excitement in the nucleotide modification problem [LiteratureReference:6793744] SnoRNA-guided ribose methylation of rRNA: structural features of the guide RNA duplex influencing the extent of the reaction [LiteratureReference:6790793] A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly [LiteratureReference:6793694] Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins [LiteratureReference:6793696] Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP [LiteratureReference:6793704] Protein-protein and protein-RNA contacts both contribute to the 15.5K-mediated assembly of the U4/U6 snRNP and the box C/D snoRNPs [LiteratureReference:6807393] Modified Method of rRNA Structure Analysis Reveals Novel Characteristics of Box C/D RNA Analogues
modified	[InstanceEdit:6791012] May, Bruce, 2015-08-16 [InstanceEdit:6793747] May, Bruce, 2015-09-04 [InstanceEdit:6807399] May, Bruce, 2015-11-01 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8856927] May, Bruce, 2016-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides
output	[EntityWithAccessionedSequence:6790604] pre-rRNA containing 2'-O-methylribonucleotides [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:74992] Dissociation of PTRF:RNA Polymerase I:pre-rRNA complex [Homo sapiens] [Reaction:74993] PTRF binds the paused RNA Polymerase I complex [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30 [InstanceEdit:8856924] Sharma, Sunny, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860953] R-HSA-6790907.2
summation	[Summation:6790977] The Fibrillarin (FBL) component of Box C/D small nucleolar r...
(hasEvent)	[Pathway:6790901] rRNA modification in the nucleus and cytosol [Homo sapiens]
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