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Details on Person EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248

Class:Id	Reaction:6790906
_displayName	EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248
_doRelease	TRUE
_timestamp	2016-02-19 18:19:33
authored	[InstanceEdit:6790729] May, Bruce, 2015-08-14
catalystActivity	[CatalystActivity:6790902] rRNA (pseudouridine) methyltransferase activity of SSU Processome [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644076] rRNA (pseudouridine) methyltransferase activity of SSU Processome [nucleoplasm] The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6790904] May, Bruce, 2015-08-15
edited	[InstanceEdit:6790729] May, Bruce, 2015-08-14
goBiologicalProcess	[GO_BiologicalProcess:161509] rRNA methylation
inferredFrom	[Reaction:6790936] EMG1 of the SSU processome methylates pseudouridine-1191 of 18S rRNA yielding N(1)-methylpseudouridine-1191 [Saccharomyces cerevisiae]
input	[SimpleEntity:77087] AdoMet [nucleoplasm] [EntityWithAccessionedSequence:6790694] pre-rRNA containing pseudouridine [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790799] The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase [LiteratureReference:6790938] Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome [LiteratureReference:6792479] Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis
modified	[InstanceEdit:6790955] May, Bruce, 2015-08-15 [InstanceEdit:6792486] May, Bruce, 2015-08-24 [InstanceEdit:6793747] May, Bruce, 2015-09-04 [InstanceEdit:6798639] May, Bruce, 2015-09-21 [InstanceEdit:8855037] May, Bruce, 2016-01-30 [InstanceEdit:8856927] May, Bruce, 2016-02-12 [InstanceEdit:8858394] May, Bruce, 2016-02-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248
output	[GenomeEncodedEntity:6790887] 18SE pre-rRNA containing 1-methylpseudoU-1248 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:6790905] Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA [Homo sapiens] [Reaction:74992] Dissociation of PTRF:RNA Polymerase I:pre-rRNA complex [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30 [InstanceEdit:8856924] Sharma, Sunny, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860952] R-HSA-6790906.3
summation	[Summation:6793740] EMG1 (NEP1) methylates a pseudouridine residue in precursor ...
(hasEvent)	[Pathway:6790901] rRNA modification in the nucleus and cytosol [Homo sapiens]
(precedingEvent)	[Reaction:8868783] TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 [Homo sapiens]
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No pathways have been reviewed or authored by EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (6790906)