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Details on Person Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
| Class:Id | LiteratureReference:6790314 |
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| _displayName | Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling |
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| _timestamp | 2015-08-10 14:39:28 |
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| author | [Person:6790313] Röring, Michael
[Person:5674473] Herr, Ricarda
[Person:6790312] Fiala, Gina J
[Person:6790315] Heilmann, Katharina
[Person:5674466] Braun, Sandra
[Person:6790311] Eisenhardt, Anja E
[Person:6790319] Halbach, Sebastian
[Person:4613361] Capper, David
[Person:5687540] von Deimling, Andreas
[Person:6790316] Schamel, Wolfgang W
[Person:6790318] Saunders, Darren N
[Person:5674451] Brummer, Tilman |
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| created | [InstanceEdit:6790317] Rothfels, Karen, 2015-08-10 |
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| journal | EMBO J. |
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| pages | 2629-47 |
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| pubMedIdentifier | 22510884 |
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| title | Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling |
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| volume | 31 |
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| year | 2012 |
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| (literatureReference) | [Reaction:6802911] High kinase activity BRAF complexes phosphorylate MAP2Ks [Homo sapiens]
[Reaction:6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs [Homo sapiens]
[Reaction:6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs [Homo sapiens]
[Reaction:6802916] RAF is phosphorylated downstream of moderate kinase activity BRAF mutants [Homo sapiens]
[Reaction:6802919] RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks [Homo sapiens]
[Reaction:6802921] Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants [Homo sapiens]
[Reaction:6802924] RAF is phosphorylated downstream of oncogenic RAS [Homo sapiens]
[Reaction:6802937] Inactive BRAF mutants bind mutant RAS:GTP [Homo sapiens]
[Pathway:6802946] Signaling by moderate kinase activity BRAF mutants [Homo sapiens]
[Pathway:6802948] Signaling by high-kinase activity BRAF mutants [Homo sapiens] |
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