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Details on Person Signal transducer and activator of transcription 3 (STAT3) i...

Class:Id	Summation:6789688
_displayName	Signal transducer and activator of transcription 3 (STAT3) i...
_timestamp	2015-09-10 16:05:11
created	[InstanceEdit:6789598] Jupe, Steve, 2015-08-03
literatureReference	[LiteratureReference:6789554] Stat3 regulates genes common to both wound healing and cancer [LiteratureReference:6789601] Evaluation of potential Stat3-regulated genes in human breast cancer [LiteratureReference:6789584] Identification of novel direct Stat3 target genes for control of growth and differentiation [LiteratureReference:6789622] STAT3 Target Genes Relevant to Human Cancers [LiteratureReference:6789583] The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins [LiteratureReference:6789772] Mechanism of interferon-gamma mediated down-regulation of interleukin-10 gene expression [LiteratureReference:6789768] Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment [LiteratureReference:6789751] Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1 [LiteratureReference:6789717] Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells [LiteratureReference:6789742] Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis [LiteratureReference:6789737] STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis [LiteratureReference:6789761] Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene [LiteratureReference:6789820] Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth [LiteratureReference:6793970] Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3 [LiteratureReference:6789833] Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing [LiteratureReference:6789839] Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression [LiteratureReference:6789801] Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis [LiteratureReference:6789810] STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production [LiteratureReference:6789856] Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells [LiteratureReference:6789916] STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6 [LiteratureReference:6789949] Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis [LiteratureReference:6789917] Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene
modified	[InstanceEdit:6789729] Jupe, Steve, 2015-08-04 [InstanceEdit:6789807] Jupe, Steve, 2015-08-04 [InstanceEdit:6789930] Jupe, Steve, 2015-08-06 [InstanceEdit:6793965] Jupe, Steve, 2015-09-04 [InstanceEdit:6797418] Jupe, Steve, 2015-09-10
text	Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M (OSM), and leukemia inhibitory factor (LIF). Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some have been confirmed as direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes for extracellular proteins that are upregulated by STAT3 include Lipopolysaccharide-binding protein (LBP) (Schumann et al. 1996), IL10 (Schaefer et al. 2009), IL23A (Kortylewski et al. 2009), Transforming growth factor beta-1 (TGFB1) (Kinjyo et al. 2006), Matrix metalloproteinase-1 (MMP1, Interstitial collagenase) (Itoh et al. 2006), MMP2 (Xie et al. 2004), MMP3 (Liu et al. 2013), MMP9 (Song et al. 2009), Neutrophil gelatinase-associated lipocalin (LCN2) (Jung et al. 2012, Xu et al. 2015), Pro-opiomelanocortin (POMC) (Bosquet et al. 2000), Serum amyloid A-1 protein (SAA1) (Hagihara et al. 2005), Vascular endothelial growth factor A (VEGFA) (Niu et al. 2002), Fibroblast growth factor 2 (FGF2) (Huang et al. 2013), Hepatocyte growth factor (HGF) (Hung & Elliot 2001), IL17A, IL17F (Durant et al. 2010) and Metalloproteinase inhibitor 1 (TIMP1) (Adamson et al. 2013).
(summation)	[BlackBoxEvent:6789615] Expression of STAT3-upregulated extracellular proteins [Homo sapiens] [BlackBoxEvent:6790040] STAT3 upregulated transcription of MUC1 [Homo sapiens]
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