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Details on Person Expression of STAT3-upregulated extracellular proteins
Class:Id BlackBoxEvent:6789615 _displayName Expression of STAT3-upregulated extracellular proteins _doRelease TRUE _timestamp 2019-05-06 22:20:13 authored [InstanceEdit:6785864] Jupe, Steve, 2015-07-01 compartment [Compartment:984] extracellular region [Compartment:7660] nucleoplasm created [InstanceEdit:6789598] Jupe, Steve, 2015-08-03 edited [InstanceEdit:8937485] Jupe, Steve, 2016-09-02 input [DefinedSet:6790043] STAT3-upregulated genes for extracellular proteins [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:6789622] STAT3 Target Genes Relevant to Human Cancers [LiteratureReference:6789583] The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins [LiteratureReference:6789772] Mechanism of interferon-gamma mediated down-regulation of interleukin-10 gene expression [LiteratureReference:6789768] Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment [LiteratureReference:6789751] Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1 [LiteratureReference:6789717] Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells [LiteratureReference:6789742] Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis [LiteratureReference:6789737] STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis [LiteratureReference:6789761] Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene [LiteratureReference:6789820] Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth [LiteratureReference:6793970] Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3 [LiteratureReference:6789833] Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing [LiteratureReference:6789839] Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression [LiteratureReference:6789801] Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis [LiteratureReference:6789810] STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production [LiteratureReference:6789856] Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells [LiteratureReference:6789916] STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6 [LiteratureReference:6789949] Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis [LiteratureReference:6789917] Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene modified [InstanceEdit:6789807] Jupe, Steve, 2015-08-04 [InstanceEdit:6789930] Jupe, Steve, 2015-08-06 [InstanceEdit:6790027] Jupe, Steve, 2015-08-06 [InstanceEdit:6797246] Jupe, Steve, 2015-09-07 [InstanceEdit:6797418] Jupe, Steve, 2015-09-10 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8937483] Jupe, Steve, 2016-09-02 [InstanceEdit:8937493] Jupe, Steve, 2016-09-02 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9645203] D'Eustachio, Peter, 2019-05-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Expression of STAT3-upregulated extracellular proteins output [DefinedSet:6790034] STAT3-upregulated extracellular proteins [extracellular region] [Homo sapiens] precedingEvent
regulatedBy [PositiveRegulation:6797262] Positive regulation by 'p-Y705-STAT3 dimer [nucleoplasm]' releaseDate 2016-12-12 reviewed [InstanceEdit:8937491] Leibovich, Samuel, 2016-09-02 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:8908849] R-HSA-6789615.4 summation [Summation:6789688] Signal transducer and activator of transcription 3 (STAT3) i... (hasEvent) [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling [Homo sapiens]
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