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Details on Person In human peripheral blood, monocytes Interleukin-4 (IL4) and...

Class:IdSummation:6789492
_displayNameIn human peripheral blood, monocytes Interleukin-4 (IL4) and...
_timestamp2018-01-08 16:48:05
created[InstanceEdit:6789519] Jupe, Steve, 2015-07-31
literatureReference[LiteratureReference:6789484] Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13
modified[InstanceEdit:6789532] Jupe, Steve, 2015-07-31
[InstanceEdit:6797572] Jupe, Steve, 2015-09-14
[InstanceEdit:9012702] Duenas, Corina, 2017-07-18
[InstanceEdit:9013296] Duenas, Corina, 2017-07-24
[InstanceEdit:9013348] Duenas, Corina, 2017-07-24
[InstanceEdit:9024301] Duenas, Corina, 2017-10-03
[InstanceEdit:9034599] Jupe, Steve, 2018-01-08
textIn human peripheral blood, monocytes Interleukin-4 (IL4) and Interleukin-13 significantly downregulate the expression of classical proinflammatory signal transducers, such as Interleukin-1 (IL1), Interleukin-6, Interleukin-8, Interleukin-18, C-C motif chemokine 2 (CCL2) and Tumor necrosis factor (TNF). Expression of Prostaglandin G/H synthase 2 (PTGS2, COX2) and Arachidonate 5-lipoxygenase (ALOX5), enzymes involved in the biosynthesis of the proinflammatory eicosanoids, is also attenuated (Chatidis et al. 2005).
This is a black box event because the mechanism of gene regulation is not fully defined.
(summation)[BlackBoxEvent:6789524] Expression of IL4,IL13-downregulated extracellular genes [Homo sapiens]
[BlackBoxEvent:6797293] Expression of IL18, ALOX5 [Homo sapiens]
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